Impact of pneumococcal conjugate vaccine 13 introduction on severe lower respiratory tract infections associated with respiratory syncytial virus or influenza virus in hospitalized children in Ulaanbaatar, Mongolia.

Autor: Do LAH; New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Tsedenbal N; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Khishigmunkh C; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Tserendulam B; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Altanbumba L; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Luvsantseren D; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Ulziibayar M; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Suuri B; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Narangerel D; Ministry of Health, National Center for Communicable Diseases, Ulaanbaatar, Mongolia., Tsolmon B; National Center of Communicable Diseases, Ulaanbaatar, Mongolia.; Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Demberelsuren S; Expanded Programme on Immunization, World Health Organization, Ulaanbaatar, Mongolia., Nguyen C; New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Mungun T; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., von Mollendorf C; New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Badarch D; National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Mulholland K; New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.; London School of Hygiene and Tropical Medicine, London, United Kingdom.
Jazyk: angličtina
Zdroj: IJID regions [IJID Reg] 2024 Mar 19; Vol. 11, pp. 100357. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).
DOI: 10.1016/j.ijregi.2024.100357
Abstrakt: Objectives: Limited data indicate a beneficial effect of pneumococcal conjugate vaccines (PCVs) on respiratory syncytial virus (RSV) and influenza infections in young children. We evaluated the impact of 13-valent PCV (PCV13) introduction on the incidence of severe lower respiratory tract infections (LRTIs) associated with RSV or influenza in hospitalized children.
Methods: Our study was restricted to children aged <2 years with arterial oxygen saturation <93% and children with radiologically confirmed pneumonia nested in a pneumonia surveillance project in four districts of Ulaanbaatar city, Mongolia. We tested nasopharyngeal swabs collected on admission for RSV and influenza using quantitative reverse transcription-polymerase chain reaction. The impact of PCV13 on the incidence of LRTI outcomes associated with RSV or with influenza for the period April 2015-March 2020 was estimated. Incidence rate ratios comparing pre- and post-vaccine periods were estimated for each outcome for each district using negative binomial models and for all districts combined with a mixed-effects negative binomial model. Adjusted models accounted for seasonality. Sensitivity analyses were conducted to assess the robustness of our findings.
Results: Among 5577 tested cases, the adjusted incidence rate ratios showed a trend toward a reduction in RSV-associated outcomes: all LRTIs (0.77, 95% confidence interval [CI] 0.44-1.36), severe LRTIs (0.88, 95% CI 0.48-1.62), very severe LRTIs (0.76, 95% CI 0.42-1.38), and radiologically confirmed pneumonia (0.66, 95% CI 0.32-1.38) but inconsistent trends in outcomes associated with influenza.
Conclusions: No significant reductions were observed in any outcomes associated with RSV and influenza after PCV introduction.
Competing Interests: The authors have no competing interests to declare.
(© 2024 The Authors.)
Databáze: MEDLINE