Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-κβ/TNF-α Axis in Breast Cancer.

Autor: Abdel-Samed SA; Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62511 Egypt., Hozyen WG; Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62511 Egypt., Shaaban SM; Department of Oncology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt., Hasona NA; Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62511 Egypt.
Jazyk: angličtina
Zdroj: Indian journal of clinical biochemistry : IJCB [Indian J Clin Biochem] 2024 Apr; Vol. 39 (2), pp. 226-232. Date of Electronic Publication: 2022 Nov 27.
DOI: 10.1007/s12291-022-01101-4
Abstrakt: Serum microRNAs (miRs) have recently been proposed as potential cancer biomarkers for early detection. Thyroid hormones play a crucial role in human health, and their alterations are linked to a range of diseases, such as breast cancer. The relationship between NF-κβ, TNF-α, and non-coding RNAs is an urgent need for clinical trials. This study aimed to investigate serum expression folds of miR-155 and miR-375 and their correlations with NF-κβ and TNF-α in breast cancer patients. The current study was conducted on 183 unrelated female participants. Serum levels of free T3 and T4, as well as expression folds of miR-155 and miR-375, were significantly higher in patients with fibroadenoma and breast cancer, despite TSH being significantly lower. Additionally, the signaling of TNF-alpha and NF-κβ were found to be significantly upregulated in the serum of patients with breast cancer. Up-regulation of miR-155 and miR-375 expression may be diagnostic biomarkers of breast cancer, pointing to the role of NF-κβ and TNF-α expression in miR-155 and miR-375 expression as therapeutic targets of breast cancer in the future.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
(© The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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