Circulating miRNA-21 is an innovative biomarker for cardiovascular events in erectile dysfunction patients.
| Autor: | Agulló L; Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Institute of Bioengineering, Miguel Hernández University, Elche, Spain., Segura A; Andrology Unit, Urology Department, Dr. Balmis General University Hospital, Alicante, Spain., Ortuño-Miquel S; Bioinformatics Department, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain., Brinca AT; Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal., Micol-Ponce R; Institute of Bioengineering, Miguel Hernández University, Elche, Spain., Arrarte V; Cardiology Department, Dr. Balmis General University Hospital, Alicante, Spain., Ponce MR; Institute of Bioengineering, Miguel Hernández University, Elche, Spain., Miró-Martínez P; Department of Statistics and Operational Research of the Alcoy Campus of Universitat Politècnica de València, Alicante, Spain., Zandonai T; Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Addiction Science Lab, Department of Psychology and Cognitive Science, University of Trento, Rovereto, Italy., Peiró AM; Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Institute of Bioengineering, Miguel Hernández University, Elche, Spain. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Mar 21; Vol. 11, pp. 1301925. Date of Electronic Publication: 2024 Mar 21 (Print Publication: 2024). |
| DOI: | 10.3389/fcvm.2024.1301925 |
| Abstrakt: | Introduction: It is well-known that circulating microRNAs (miRNAs) play a relevant role in many kinds of diseases by regulating the expression of genes involved in various pathophysiologic processes, including erectile dysfunction (ED) and cardiovascular diseases (CVD). Purpose: This study aimed to identify the miRNA-21 profile in the blood samples of patients with ED, CVD, and the combination of both pathologies to elucidate the potential function of miRNA-21. Methods: A total of 45 patients with CVD and/or who underwent the erectile function test were included and divided into the following categories: CVD with ED (cases, n = 29) and controls ( n = 16) with either ED or CVD. Real-time polymerase chain reaction analysis verified the results. miRNA-21 expression was quantified, and informatics analysis was applied to predict the functions of this differentially expressed miRNA-21. Results: A total of 64% of cases (63 ± 9 years, 66% with severe ED, 56% with CV ejection fraction) first presented ED as the sentinel clinical manifestation. Serum miRNA-21 levels in the control ED were significant, up to 10-fold higher than in the CVD controls and cases. A significant inverse ( p = 0.0368, β = -2.046) correlation was found between erectile function and miRNA-21 levels. Conclusions: Our study provides comprehensive insights into the functional interaction between miRNA-21 and ED in CVD patients. Its relevance lies in the potential of miRNA as a biomarker to be applied in the cardiovascular predictive medicine field. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor SR declared a shared affiliation with author TZ at the time of review. (© 2024 Agulló, Segura, Ortuño‐Miquel, Brinca, Micol-Ponce, Arrarte, Ponce, Miró-Martínez, Zandonai and Peiró.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|