Harzianic acids and oxazolidinone from the endophytic fungus Ilyonectria sp. and their cytotoxicity activity.
| Autor: | Tong SY; School of Pharmaceutical Science, South-Central Minzu University, Wuhan, Hubei 430074, China., Ye K; School of Pharmaceutical Science, South-Central Minzu University, Wuhan, Hubei 430074, China., Wang WX; School of Pharmacy, Chongqing Three Gorges Medical College, Chongqing 404120, China. Electronic address: wangwenxiang@cqtgmc.edu.cn., Ai HL; School of Pharmaceutical Science, South-Central Minzu University, Wuhan, Hubei 430074, China. Electronic address: aihonglian05@163.com. |
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| Jazyk: | angličtina |
| Zdroj: | Fitoterapia [Fitoterapia] 2024 Jun; Vol. 175, pp. 105941. Date of Electronic Publication: 2024 Apr 02. |
| DOI: | 10.1016/j.fitote.2024.105941 |
| Abstrakt: | Four undescribed compounds including three harzianic acids (1, 3 and 4) and one oxazolidinone (2), along with three known ones (5-7) were isolated from the solid fermented product of endophytic fungus Ilyonectria sp., their structures were elucidated as 1-amino-harzianic acid (1), ilyonectria-oxazolidinone (2),10'-nor- isoharzianic acid (3), isohomoharzianic acid (4), harzianic acid (5), isoharzianic acid (6), homoharzianic acid (7) by means of detailed chemical evidences and spectroscopic data analysis. All the compounds were evaluated for cytotoxicity against SMMC-7721 human cancer cell lines by MTS assay. Among the seven tested compounds, 1-amino-harzianic acid (1) demonstrated well cytotoxic activity against SMMC-7721 with IC Competing Interests: Declaration of competing interest The authors declared that they have no conflicts of interest to this work. We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted. (Copyright © 2023. Published by Elsevier B.V.) |
| Databáze: | MEDLINE |
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