Evaluation of in silico model predictions for mammalian acute oral toxicity and regulatory application in pesticide hazard and risk assessment.
Autor: | Bishop PL; Animal Research Issues, The Humane Society of the United States, Washington, DC, USA. Electronic address: pbishop@humanesociety.org., Mansouri K; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Eckel WP; US Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA., Lowit MB; US Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA., Allen D; Predictive Toxicology and Information Sciences Group, Discovery and Safety Assessment Division, Inotiv, Morrisville, NC, USA., Blankinship A; US Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA., Lowit AB; US Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, DC, USA., Harwood DE; US Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA., Johnson T; US Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, USA., Kleinstreuer NC; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. |
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Jazyk: | angličtina |
Zdroj: | Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2024 May; Vol. 149, pp. 105614. Date of Electronic Publication: 2024 Apr 02. |
DOI: | 10.1016/j.yrtph.2024.105614 |
Abstrakt: | The United States Environmental Protection Agency (USEPA) uses the lethal dose 50% (LD Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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