Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer.

Autor:	Dey T; School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneshwar 751024, Odisha, India., Ghosh A; School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneshwar 751024, Odisha, India., Sanyal A; School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneshwar 751024, Odisha, India., Charles CJ; Department of Biotechnology, Vellore Institute of Technology, Vellore 632014, India., Pokharel S; School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneshwar 751024, Odisha, India., Nair L; Department of Pharmaceutical Sciences, Assam Central University, Silchar 788011, Assam, India., Singh M; Department of Pharmaceutical Sciences, Assam Central University, Silchar 788011, Assam, India., Kaity S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical, Education and Research, Kolkata, West Bengal 700054, India., Ravichandiran V; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical, Education and Research, Kolkata, West Bengal 700054, India., Kaur K; Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons, Dublin 2 D02YN77, Ireland.; Department of Pharmacy & Biomolecular Science, Royal College of Surgeons, Dublin 2 D02YN77, Ireland., Roy S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical, Education and Research, Kolkata, West Bengal 700054, India.
Jazyk:	angličtina
Zdroj:	Biomedical materials (Bristol, England) [Biomed Mater] 2024 Apr 15; Vol. 19 (3). Date of Electronic Publication: 2024 Apr 15.
DOI:	10.1088/1748-605X/ad3abb
Abstrakt:	In terms of biomedical tools, nanodiamonds (ND) are a more recent innovation. Their size typically ranges between 4 to 100 nm. ND are produced via a variety of methods and are known for their physical toughness, durability, and chemical stability. Studies have revealed that surface modifications and functionalization have a significant influence on the optical and electrical properties of the nanomaterial. Consequently, surface functional groups of NDs have applications in a variety of domains, including drug administration, gene delivery, immunotherapy for cancer treatment, and bio-imaging to diagnose cancer. Additionally, their biocompatibility is a critical requisite for their in vivo and in vitro interventions. This review delves into these aspects and focuses on the recent advances in surface modification strategies of NDs for various biomedical applications surrounding cancer diagnosis and treatment. Furthermore, the prognosis of its clinical translation has also been discussed. (© 2024 IOP Publishing Ltd.)
Databáze:	MEDLINE
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