The Relationship between Neurobiological Function and Inflammation in Depressed Children and Adolescents: A Scoping Review.

Autor:	Schumacher A; Department of Psychiatry, The Hospital for Sick Children, Toronto, Ontario, Canada, anett.schumacher@sickkids.ca., Muha J; Department of Psychiatry, The Hospital for Sick Children, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Campisi SC; Department of Psychiatry, The Hospital for Sick Children, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Bradley-Ridout G; Gerstein Science Information Centre, University of Toronto, Toronto, Ontario, Canada., Lee ACH; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada., Korczak DJ; Department of Psychiatry, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Neuropsychobiology [Neuropsychobiology] 2024; Vol. 83 (2), pp. 61-72. Date of Electronic Publication: 2024 Apr 04.
DOI:	10.1159/000538060
Abstrakt:	Introduction: Neurobiological dysfunction is associated with depression in children and adolescents. While research in adult depression suggests that inflammation may underlie the association between depression and brain alterations, it is unclear if altered levels of inflammatory markers provoke neurobiological dysfunction in early-onset depression. The aim of this scoping review was to provide an overview of existing literature investigating the potential interaction between neurobiological function and inflammation in depressed children and adolescents. Methods: Systematic searches were conducted in six databases. Primary research studies that included measures of both neurobiological functioning and inflammation among children (≤18 years) with a diagnosis of depression were included. Results: Four studies (240 participants; mean age 16.0 ± 0.6 years, 62% female) meeting inclusion criteria were identified. Studies primarily examined the inflammatory markers interleukin 6, tumor necrosis factor alpha, C-reactive protein, and interleukin 1 beta. Exploratory whole brain imaging and analysis as well as region of interest approaches focused on the anterior cingulate cortex, basal ganglia, and white matter tracts were conducted. Most studies found correlations between neurobiological function and inflammatory markers; however, depressive symptoms were not observed to moderate these effects. Conclusions: A small number of highly heterogeneous studies indicate that depression may not modulate the association between altered inflammation and neurobiological dysfunction in children and adolescents. Replication in larger samples using consistent methodological approaches (focus on specific inflammatory markers, examine certain brain areas) is needed to advance the knowledge of potential neuro-immune interactions early in the course of depression. (© 2024 The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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