Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study.

Autor: Bollack A; Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, London, UK., Collij LE; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.; Amsterdam Neuroscience, Brain Imaging, VU University Amsterdam, Amsterdam, The Netherlands., García DV; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands., Shekari M; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; Instituto de investigaciones médicas Hospital del Mar (IMIM), Barcelona, Spain., Altomare D; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Payoux P; Department of Nuclear Medicine, Imaging Pole, Toulouse University Hospital, Toulouse, France.; Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, CHU Purpan, Pavillon Baudot, Place du Docteur Joseph Baylac, Toulouse, France., Dubois B; Department of Neurology, Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France., Grau-Rivera O; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Boada M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Marquié M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Nordberg A; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden., Walker Z; Division of Psychiatry, University College London, London, UK.; Essex Partnership University NHS Foundation Trust, The Lodge, Wickford, UK., Scheltens P; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Alzheimercentrum Amsterdam, Amsterdam, The Netherlands., Schöll M; Wallenberg Centre for Molecular and Translational Medicine, The University of Gothenburg, Gothenburg, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Wolz R; IXICO Plc, London, UK., Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Gismondi R; Life Molecular Imaging, GmbH, Berlin, Germany., Stephens A; Life Molecular Imaging, GmbH, Berlin, Germany., Buckley C; GE HealthCare, Buckinghamshire, UK., Frisoni GB; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Hanseeuw B; Department of Neurology, Institute of Neuroscience, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.; WELBIO Department, WEL Research Institute, Wavre, Belgium., Visser PJ; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Vandenberghe R; Laboratory for Cognitive Neurology, LBI - KU Leuven Brain Institute, Leuven, Belgium., Drzezga A; Department of Nuclear Medicine, University Hospital Cologne, Universitätsklinikums Köln, Köln, Germany.; Molecular Organization of the Brain, Institute for Neuroscience and Medicine, INM-2), Forschungszentrum Jülich GmbH, Jülich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Yaqub M; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands., Boellaard R; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Gispert JD; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Madrid, Spain., Markiewicz P; Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, London, UK.; Computer Science and Informatics, School of Engineering, London South Bank University, London, UK., Cash DM; Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute at University College London, London, UK., Farrar G; GE HealthCare, Buckinghamshire, UK., Barkhof F; Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, London, UK.; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands.; Queen Square Institute of Neurology, University College London, London, UK.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 May; Vol. 20 (5), pp. 3429-3441. Date of Electronic Publication: 2024 Apr 04.
DOI: 10.1002/alz.13761
Abstrakt: Introduction: To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations.
Methods: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [ 18 F]flutemetamol, [ 18 F]florbetaben or [ 18 F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95 th percentile of longitudinal measurements in sub-populations (N PNHS  = 101/750, N Insight46  = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision-recall analyses. Accumulation rates were examined using linear mixed-effect models.
Results: Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ-accumulators. Rates of amyloid accumulation were tracer-independent, lower for APOE ε4 non-carriers, and for subjects with higher levels of education.
Discussion: Our results support a 12-20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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