Surveillance for Emerging and Reemerging Pathogens Using Pathogen Agnostic Metagenomic Sequencing in the United States: A Critical Role for Federal Government Agencies.
Autor: | Downie DL; Diane L. Downie, PhD, MPH, is Deputy Associate Director for Science, Office of Readiness and Response, US Centers for Disease Control and Prevention, Atlanta, GA., Rao P; Preetika Rao, MPH, is a Health Scientist, US Centers for Disease Control and Prevention, Atlanta, GA., David-Ferdon C; Corinne David-Ferdon, PhD, is Associate Director of Science, Office of Public Health Data, Surveillance, and Technology, US Centers for Disease Control and Prevention, Atlanta, GA., Courtney S; Sean Courtney, PhD, is a Health Scientist, US Centers for Disease Control and Prevention, Atlanta, GA., Lee JS; Justin S. Lee, DVM, PhD, is a Health Scientist, Division of Global Health Protection, US Centers for Disease Control and Prevention, Atlanta, GA., Quiner C; Claire Quiner, MPH, MCP, is a Research Public Health Analyst, Social, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC., MacDonald PDM; Pia D. M. MacDonald, PhD, MPH, is a Senior Infectious Disease Epidemiologist, Social, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC., Barnes K; Keegan Barnes is a Public Health Analyst, Social, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC., Fisher S; Shelby Fisher, MPH, is an Epidemiologist, Social, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC., Andreadis JL; Joanne L. Andreadis, PhD, is Associate Director for Science, US Centers for Disease Control and Prevention, Atlanta, GA., Chaitram J; Jasmine Chaitram, MPH, is Branch Chief, US Centers for Disease Control and Prevention, Atlanta, GA., Mauldin MR; Matthew R. Mauldin, PhD, is Health Scientists US Centers for Disease Control and Prevention, Atlanta, GA., Salerno RM; Reynolds M. Salerno, PhD, is Director, Division of Laboratory Systems, US Centers for Disease Control and Prevention, Atlanta, GA., Schiffer J; Jarad Schiffer, MS, is Health Scientists, Office of Readiness and Response, US Centers for Disease Control and Prevention, Atlanta, GA., Gundlapalli AV; Adi V. Gundlapalli, MD, PhD, is a Senior Advisor, Data Readiness and Response, Office of Public Health Data, Surveillance, and Technology, US Centers for Disease Control and Prevention, Atlanta, GA. |
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Jazyk: | angličtina |
Zdroj: | Health security [Health Secur] 2024 Mar-Apr; Vol. 22 (2), pp. 85-92. Date of Electronic Publication: 2024 Apr 04. |
DOI: | 10.1089/hs.2023.0099 |
Abstrakt: | The surveillance and identification of emerging, reemerging, and unknown infectious disease pathogens is essential to national public health preparedness and relies on fluidity, coordination, and interconnectivity between public and private pathogen surveillance systems and networks. Developing a national sentinel surveillance network with existing resources and infrastructure could increase efficiency, accelerate the identification of emerging public health threats, and support coordinated intervention strategies that reduce morbidity and mortality. However, implementing and sustaining programs to detect emerging and reemerging pathogens in humans using advanced molecular methods, such as metagenomic sequencing, requires making large investments in testing equipment and developing networks of clinicians, laboratory scientists, and bioinformaticians. In this study, we sought to gain an understanding of how federal government agencies currently support such pathogen agnostic testing of human specimens in the United States. We conducted a landscape analysis of federal agency websites for publicly accessible information on the availability and type of pathogen agnostic testing and details on flow of clinical specimens and data. The website analysis was supplemented by an expert review of results with representatives from the federal agencies. Operating divisions within the US Department of Health and Human Services and the US Department of Veterans Affairs have developed and sustained extensive clinical and research networks to obtain patient specimens and perform metagenomic sequencing. Metagenomic facilities supported by US agencies were not equally geographically distributed across the United States. Although many entities have work dedicated to metagenomics and/or support emerging infectious disease surveillance specimen collection, there was minimal formal collaboration across agencies. |
Databáze: | MEDLINE |
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