Respiratory Syncytial Virus vs Influenza Virus Infection: Mortality and Morbidity Comparison Over 7 Epidemic Seasons in an Elderly Population.

Autor:	Recto CG; Assistance Publique-Hopitaux de Paris, Henri Mondor University Hospital, Department of Internal Medicine and Geriatrics, F-94010 Creteil's Paris-Est University., Fourati S; Virology Department, Henri Mondor University Hospital, Paris-Est University and INSERM U955, Creteil's Paris-Est University., Khellaf M; Emergency Department, Assistance Publique-Hopitaux de Paris, Henri Mondor University Hospital, Paris EST Creteil University., Pawlotsky JM; Virology Department, Henri Mondor University Hospital, Paris-Est University and INSERM U955, Creteil's Paris-Est University., De Prost N; Service de Medecine Intensive Reanimation, Hopitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hopitaux de Paris.; Groupe de Recherche Clinique CARMAS, Creteil's Paris-Est University, Creteil., Diakonoff H; Institution Nationale des Invalides, Institut Droit et Santé, Inserm UMR_S 1145, Université Paris Cité., Donadio C; University Hospital Pitié-Salpêtrière-Charles Foix, Geriatric Department, Assistance Publique-Hopitaux de Paris, Sorbonne University., Pouga L; Virology Department, Henri Mondor University Hospital, Paris-Est University and INSERM U955, Creteil's Paris-Est University., de Tymowski C; Department of Anaesthesiology and Surgical Intensive Care, DMU PARABOL, Assistance Publique-Hopitaux de Paris, Hôpital Bichat, Paris, France., Kassasseya C; Emergency Department, Assistance Publique-Hopitaux de Paris, Henri Mondor University Hospital, Paris EST Creteil University.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Nov 15; Vol. 230 (5), pp. 1130-1138.
DOI:	10.1093/infdis/jiae171
Abstrakt:	Background: Respiratory syncytial virus (RSV) infection is gaining interest due to the recent development of vaccines but is still misdiagnosed in the elderly. The primary objective was to compare all-cause mortality at day 30. Secondary objectives were to compare clinical presentation and rates of consolidative pneumonia, hospitalization, and intensive care unit (ICU) admission. Methods: A single-center retrospective study was conducted in a French university hospital during 7 epidemic seasons including 558 patients aged ≥75 years: 125 with RSV and 433 with influenza (median age, 84.8 years). Results: Patients with RSV had more respiratory symptoms (wheezing, dyspnea) whereas patients with influenza had more general symptoms (fever, asthenia, myalgia). The following were higher in the RSV group: consolidative pneumonia (28.8% vs 17.2%, P = .004), hospitalization (83.2% vs 70%, P = .003), ICU admission (7.2% vs 3.0%, P = .034), and length of stay (median [IQR], 9 days [2-16] vs 5 days [0-12]; P = .002). Mortality rates at day 30 were comparable (9.6% vs 9.7%, P = .973). Conclusions: This study included the largest cohort of patients infected with RSV aged >75 years documented in-depth thus far. RSV shares a comparable mortality rate with influenza but is associated with higher rates of consolidative pneumonia, hospitalization, ICU admissions, and extended hospital stays. Competing Interests: Potential conflicts of interest. Authors C. Recto, H. Diakonoff, C. Donadio, L. Pouga, C. de Tymowski, and C. Kassasseya declare no conflicts of interest. S. Fourati received consulting fees from Spikimm, AstraZeneca, GSK, Pfizer, Moderna, and Cepheid, and has received lecture fees from AstraZeneca, GSK, Pfizer, Moderna, and Cepheid. J-M. Pawlotsky received consulting fees from Abbott, AbbVie, and GSK, and has received lecture fees from AbbVie and Gilead. N. de Prost received consulting fees from AstraZeneca, and has received lecture fees from Moderna. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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