Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience.

Autor: Peraio S; Department of Neurosurgery, Meyer Children's Hospital IRCCS, Florence, Italy., Mantovani G; Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy., Araceli T; Department of Neurosurgery, Meyer Children's Hospital IRCCS, Florence, Italy.; Department of Neurosurgery, University Hospital Regensburg, Regensburg, Germany., Mongardi L; Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy., Noris A; Department of Neurosurgery, Meyer Children's Hospital IRCCS, Florence, Italy., Fino E; Pediatric Neurology Clinic - Meyer Children's Hospital IRCCS, Florence, Italy.; University of Florence, Florence, Italy., Formica F; Istituto Medea 'La Nostra Famiglia' IRCCS, Bosisio Parini, LC, Italy., Piccinini L; Istituto Medea 'La Nostra Famiglia' IRCCS, Bosisio Parini, LC, Italy., Melani F; Pediatric Neurology Clinic - Meyer Children's Hospital IRCCS, Florence, Italy., Lenge M; Pediatric Neurology Clinic - Meyer Children's Hospital IRCCS, Florence, Italy. matteo.lenge@meyer.it., Scalise R; Istituto Stella Maris - IRCCS - University of Pisa, Pisa, Italy., Battini R; Istituto Stella Maris - IRCCS - University of Pisa, Pisa, Italy., Di Rita A; Department of Neurosurgery, Meyer Children's Hospital IRCCS, Florence, Italy., D'Incerti L; Department of Radiology, Meyer Children's Hospital IRCCS, Florence, Italy., Appleton T; Department of Biology, Harding University, Searcy, AR, USA., Cavallo MA; Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy., Guerrini R; Pediatric Neurology Clinic - Meyer Children's Hospital IRCCS, Florence, Italy.; University of Florence, Florence, Italy., Giordano F; Department of Neurosurgery, Meyer Children's Hospital IRCCS, Florence, Italy.; University of Florence, Florence, Italy.
Jazyk: angličtina
Zdroj: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2024 Aug; Vol. 40 (8), pp. 2457-2464. Date of Electronic Publication: 2024 Apr 04.
DOI: 10.1007/s00381-024-06380-1
Abstrakt: Purpose: Deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) is a validated technique for the treatment of essential tremor (ET) in adults. Conversely, its use for post traumatic tremor (PTT) and in paediatric patients is still debated. We evaluated the efficacy of Vim-DBS for lesional tremor in three paediatric patients with drug-resistant post-traumatic unilateral tremor.
Methods: We retrospectively collected data regarding three patients with unilateral tremor due to severe head injury, with no MRI evidence of basal ganglia lesions. The three patients underwent stereotactic frame-based robot-assisted DBS of Vim contralateral to the tremor side.
Results: Mean follow-up was 48 months (range: 36-60 months). Tremor was reduced in all patients with a better control of voluntary movements and improvement of functional status (mean FIM scale improvement + 7 points). No surgical complications occurred.
Conclusion: Unilateral contralateral DBS of Vim could be efficacious in post-traumatic tremor, even in paediatric patients and should be offered in PTT drug-resistant patients.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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