Sex differences in Parkinson's disease-related non motor symptoms: a focus on sleep problems.

Autor: Bovenzi R; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy., Conti M; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy., De Franco V; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy., Pierantozzi M; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy.; Department of Systems Medicine, Parkinson's Disease Unit, University Hospital of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy., Schirinzi T; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy., Cerroni R; Department of Systems Medicine, Parkinson's Disease Unit, University Hospital of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy., Stefani A; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy.; Department of Systems Medicine, Parkinson's Disease Unit, University Hospital of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy., Mercuri NB; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy., Liguori C; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy. dott.claudioliguori@yahoo.it.; Department of Systems Medicine, Parkinson's Disease Unit, University Hospital of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy. dott.claudioliguori@yahoo.it.; Sleep Medicine Centre, University Hospital of Rome 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy. dott.claudioliguori@yahoo.it.
Jazyk: angličtina
Zdroj: Acta neurologica Belgica [Acta Neurol Belg] 2024 Oct; Vol. 124 (5), pp. 1525-1534. Date of Electronic Publication: 2024 Apr 04.
DOI: 10.1007/s13760-024-02535-8
Abstrakt: Parkinson's disease (PD) symptomatology differs between females and males, yet the contribution of sex on sleep problems needs further analysis. Here, we aimed to investigate sex-specific patterns in the relationship between sleep problems, assessed using the Parkinson's disease sleep scale (PDSS-2), non motor symptoms (NMS), measured by the NMS scale (NMSS), and health-related quality of life (HR-QoL), evaluated by the Parkinson's disease questionnaire (PDQ-39), in a large cohort of PD patients. One-hundred-fifty-four PD patients were included in the study. Female PD patients (n = 62) exhibited a higher prevalence of sleep problems than males (n = 92), with nocturnal motor-related sleep issues being the most frequent. Sleep disturbances differently correlated with a range of NMS between the two sexes. In females, sleep problems mostly correlated with pain; on the other hand, sleep disturbances were linked to a frailer phenotype characterized by global dysautonomia, perception disturbances, and impaired cognitive function in males. Whether female PD patients experienced a lower HR-QoL than males, sleep disturbances were associated with a worse HR-QoL in both sexes. In conclusion, sleep problems in PD differently burden the two sexes, suggesting possible different etiopathogenesis, diagnostic investigations, and possibly tailored approaches.
Competing Interests: Declarations. Competing interests: The authors have no relevant financial or non-financial interests to disclose. Ethics approval: This study was conducted in accordance with the principles of the Helsinki Declaration. The local ethics committee approved the study.
(© 2024. The Author(s).)
Databáze: MEDLINE
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