Unraveling Dysregulated Cell Signaling Pathways, Genetic and Epigenetic Mysteries of Parkinson's Disease.

Autor: Hamidpour SK; Department of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran., Amiri M; Department of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran., Ketabforoush AHME; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran., Saeedi S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA., Angaji A; Department of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran., Tavakol S; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran. shima.tavakol@yahoo.com.; Department of Research and Development, Tavakol BioMimetic Technologies Company, Tehran, Iran. shima.tavakol@yahoo.com.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2024 Nov; Vol. 61 (11), pp. 8928-8966. Date of Electronic Publication: 2024 Apr 04.
DOI: 10.1007/s12035-024-04128-1
Abstrakt: Parkinson's disease (PD) is a prevalent and burdensome neurodegenerative disorder that has been extensively researched to understand its complex etiology, diagnosis, and treatment. The interplay between genetic and environmental factors in PD makes its pathophysiology difficult to comprehend, emphasizing the need for further investigation into genetic and epigenetic markers involved in the disease. Early diagnosis is crucial for optimal management of the disease, and the development of novel diagnostic biomarkers is ongoing. Although many efforts have been made in the field of recognition and interpretation of the mechanisms involved in the pathophysiology of the disease, the current knowledge about PD is just the tip of the iceberg. By scrutinizing genetic and epigenetic patterns underlying PD, new avenues can be opened for dissecting the pathology of the disorder, leading to more precise and efficient diagnostic and therapeutic approaches. This review emphasizes the importance of studying dysregulated cell signaling pathways and molecular processes associated with genes and epigenetic alterations in understanding PD, paving the way for the development of novel therapeutic strategies to combat this devastating disease.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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