The potential of phosphorylated α-synuclein as a biomarker for the diagnosis and monitoring of multiple system atrophy.

Autor: Abdul-Rahman T; Medical Institute, Sumy State University, Sumy, Ukraine., Herrera-Calderón RE; Center for Research in Health Sciences (CICSA), Faculty of Medicine, Anahuac University North Campus, Huixquilucan, Mexico., Ahluwalia A; School of Medicine, Queen's University Belfast, Belfast, UK., Wireko AA; Medical Institute, Sumy State University, Sumy, Ukraine., Ferreira T; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Tan JK; Faculty of Medicine, University of St Andrews, St Andrews, Scotland, UK., Wolfson M; Humanitas University, Milano, Italy., Ghosh S; Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan, Bhubaneswar, India., Horbas V; Medical Institute, Sumy State University, Sumy, Ukraine., Garg V; Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India., Perveen A; Glocal School of Life Sciences, Glocal University, Saharanpur, Uttar Pradesh, India.; Princess Dr. Najla Bint Saud Al-Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, Jeddah, Saudi Arabia., Papadakis M; Department of Surgery II, University Hospital Witten-Herdecke, University of Witten-Herdecke, Wuppertal, Germany., Ashraf GM; Department of Medical Laboratory Sciences, University of Sharjah, College of Health Sciences, and Research Institute for Medical and Health Sciences, Sharjah, UAE., Alexiou A; University Centre for Research & Development, Chandigarh University, Mohali, Punjab, India.; Department of Research & Development, Athens, Greece.; Department of Research & Development, AFNP Med, Wien, Austria.; Department of Science and Engineering, Novel Global Community Educational Foundation, New South Wales, Australia.
Jazyk: angličtina
Zdroj: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Apr; Vol. 30 (4), pp. e14678.
DOI: 10.1111/cns.14678
Abstrakt: Introduction: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder characterized by the presence of glial cytoplasmic inclusions (GCIs) containing aggregated α-synuclein (α-Syn). Accurate diagnosis and monitoring of MSA present significant challenges, which can lead to potential misdiagnosis and inappropriate treatment. Biomarkers play a crucial role in improving the accuracy of MSA diagnosis, and phosphorylated α-synuclein (p-syn) has emerged as a promising biomarker for aiding in diagnosis and disease monitoring.
Methods: A literature search was conducted on PubMed, Scopus, and Google Scholar using specific keywords and MeSH terms without imposing a time limit. Inclusion criteria comprised various study designs including experimental studies, case-control studies, and cohort studies published only in English, while conference abstracts and unpublished sources were excluded.
Results: Increased levels of p-syn have been observed in various samples from MSA patients, such as red blood cells, cerebrospinal fluid, oral mucosal cells, skin, and colon biopsies, highlighting their diagnostic potential. The α-Syn RT-QuIC assay has shown sensitivity in diagnosing MSA and tracking its progression. Meta-analyses and multicenter investigations have confirmed the diagnostic value of p-syn in cerebrospinal fluid, demonstrating high specificity and sensitivity in distinguishing MSA from other neurodegenerative diseases. Moreover, combining p-syn with other biomarkers has further improved the diagnostic accuracy of MSA.
Conclusion: The p-syn stands out as a promising biomarker for MSA. It is found in oligodendrocytes and shows a correlation with disease severity and progression. However, further research and validation studies are necessary to establish p-syn as a reliable biomarker for MSA. If proven, p-syn could significantly contribute to early diagnosis, disease monitoring, and assessing treatment response.
(© 2024 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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