Highly effective decontamination in a hospital environment: An easy-to-operate, low-cost prototype.

Autor: de la Rocha C; Laboratório de Desenvolvimento de Novos Fármacos (LADEFA), Universidade Federal do Rio Grande-FURG, Rio Grande, Rio Grande do Sul, Brazil., Caprara CDSC; Laboratório de Desenvolvimento de Novos Fármacos (LADEFA), Universidade Federal do Rio Grande-FURG, Rio Grande, Rio Grande do Sul, Brazil., Poester VR; Laboratório de Micologia-Faculdade de Medicina, FURG, Rio Grande, Rio Grande do Sul, Brazil., Xavier MO; Laboratório de Micologia-Faculdade de Medicina, FURG, Rio Grande, Rio Grande do Sul, Brazil., Porte AF; Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul, Rio Grande, Rio Grande do Sul, Brazil., Galarça MM; Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul, Rio Grande, Rio Grande do Sul, Brazil., Filgueira DMVB; Laboratório de Cultura Celular-Pós-graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas-FURG, Rio Grande, Rio Grande do Sul, Brazil., Votto APS; Laboratório de Cultura Celular-Pós-graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas-FURG, Rio Grande, Rio Grande do Sul, Brazil., Ramos DF; Laboratório de Desenvolvimento de Novos Fármacos (LADEFA), Universidade Federal do Rio Grande-FURG, Rio Grande, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Photochemistry and photobiology [Photochem Photobiol] 2024 Apr 04. Date of Electronic Publication: 2024 Apr 04.
DOI: 10.1111/php.13945
Abstrakt: Healthcare-associated infections (HAI) are illnesses acquired during healthcare and are often the most important adverse event during healthcare. With the aim of increasing the effectiveness of disinfection/decontamination processes in the health service with safe and not promote microbial resistance, we propose the development of portable equipment associated with type C ultraviolet light (UVC). The efficiency of the irradiance emitted by the equipment (at dosages 3.5, 5.0, and 60 mJ/cm 2 ) was determined by the action exerted after exposure against four different bacterial (Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) and three different fungi (Candida albicans, C. parapsilosis, and Aspergillus section Fumigati). It was possible to observe that all treatments were capable of inactivating the bacterial species evaluated (p < 0.05), causing the irreversible death of these microorganisms. The most effective elimination of fungal agents was at a dose of 60 mJ/cm 2 of UVC radiation, with a decrease in the fungal inoculum varying between 94% and 100% in relation to the control without exposure. Thus, our study showed that the application of the portable prototype with UVC light (254 nm) at a distance of 48 mm, allowed an average irradiance of 3.5 mW/cm 2 , with doses of 3.5 ≈ 60 mJ/cm 2 (from 1 to 60 s of exposure), which can promote the total reduction of the bacteria evaluated and significantly reduce fungal growth. Therefore, this prototype could be used safely and effectively in the hospital environment, considerably reducing contamination and contributing to the reduction of healthcare-associated infection risk.
(© 2024 American Society for Photobiology.)
Databáze: MEDLINE
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