ECM and epithelial stem cells: the scaffold of destiny.

Autor:	Estrach S; INSERM, CNRS, IRCAN, Université Côte d'Azur, Nice, France., Vivier CM; INSERM, CNRS, IRCAN, Université Côte d'Azur, Nice, France., Féral CC; INSERM, CNRS, IRCAN, Université Côte d'Azur, Nice, France.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Mar 20; Vol. 12, pp. 1359585. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).
DOI:	10.3389/fcell.2024.1359585
Abstrakt:	Adult stem cells play a critical role in maintaining tissue homeostasis and promoting longevity. The intricate organization and presence of common markers among adult epithelial stem cells in the intestine, lung, and skin serve as hallmarks of these cells. The specific location pattern of these cells within their respective organs highlights the significance of the niche in which they reside. The extracellular matrix (ECM) not only provides physical support but also acts as a reservoir for various biochemical and biophysical signals. We will consider differences in proliferation, repair, and regenerative capacities of the three epithelia and review how environmental cues emerging from the niche regulate cell fate. These cues are transduced via mechanosignaling, regulating gene expression, and bring us to the concept of the fate scaffold. Understanding both the analogies and discrepancies in the mechanisms that govern stem cell fate in various organs can offer valuable insights for rejuvenation therapy and tissue engineering. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Estrach, Vivier and Féral.)
Databáze:	MEDLINE
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