Biophysical and biochemical aspects of immune cell-tumor microenvironment interactions.

Autor:	Benmelech S; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA., Le T; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA., McKay M; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA., Nam J; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA., Subramaniam K; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA., Tellez D; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA., Vlasak G; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA., Mak M; Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA.
Jazyk:	angličtina
Zdroj:	APL bioengineering [APL Bioeng] 2024 Apr 02; Vol. 8 (2), pp. 021502. Date of Electronic Publication: 2024 Apr 02 (Print Publication: 2024).
DOI:	10.1063/5.0195244
Abstrakt:	The tumor microenvironment (TME), composed of and influenced by a heterogeneous set of cancer cells and an extracellular matrix, plays a crucial role in cancer progression. The biophysical aspects of the TME (namely, its architecture and mechanics) regulate interactions and spatial distributions of cancer cells and immune cells. In this review, we discuss the factors of the TME-notably, the extracellular matrix, as well as tumor and stromal cells-that contribute to a pro-tumor, immunosuppressive response. We then discuss the ways in which cells of the innate and adaptive immune systems respond to tumors from both biochemical and biophysical perspectives, with increased focus on CD8+ and CD4+ T cells. Building upon this information, we turn to immune-based antitumor interventions-specifically, recent biophysical breakthroughs aimed at improving CAR-T cell therapy. Competing Interests: The authors have no conflicts to disclose. (© 2024 Author(s).)
Databáze:	MEDLINE
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