Clinical implications of seropositive and seronegative autoantibody status in rheumatoid arthritis patients: A comparative multicentre observational study.

Autor:	Hammam N; Rheumatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt., El-Husseiny PN; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Al-Adle SS; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Samy N; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Elsaid NY; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., El-Essawi DF; Health Radiation Research Department, Internal Medicine Unit, Rheumatology Clinic, (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Mohamed EF; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt., Fawzy SM; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., El Bakry SA; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Nassr M; Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Nasef SI; Rheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt., El-Saadany HM; Rheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt., Elwan S; Rheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt., Gamal NM; Rheumatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt., Moshrif A; Rheumatology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt., Hammam O; Department of Rheumatology and Rehabilitation, Faculty of Medicine, New Valley University, New Valley, Egypt., El Shereef RR; Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt., Ismail F; Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt., Tharwat S; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Mansoura University, Dakahlia, Egypt., Mosa DM; Department of Rheumatology and Rehabilitation, Mansoura University Hospitals, Mansoura University Faculty of Medicine, Mansoura, Egypt., Elazeem MIA; Rheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Abdelaleem EA; Rheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Gheita TA; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Rheumatology and immunology research [Rheumatol Immunol Res] 2024 Mar 31; Vol. 5 (1), pp. 57-65. Date of Electronic Publication: 2024 Mar 31 (Print Publication: 2024).
DOI:	10.1515/rir-2024-0007
Abstrakt:	Background and Objectives: Rheumatoid factor (RF) and anti-cyclic citrullinated protein (anti-CCP) have been used to improve the diagnosis and prognosis of rheumatoid arthritis (RA). However, their association with RA disease phenotypes, individually and in combination, is not well studied. The aim of the study was to compare patients' and disease characteristics, activity and severity in double seronegative (DNRA), single seropositive RF, single seropositive anti-CCP and double seropositive (DPRA) patients. Methods: Adults subjects with RA from Egyptian College of Rheumatology (ECR) database who had RF and anti-CCP results available were included. Demographic, clinical features, disease activity score 28 (DAS28), Health Assessment Questionnaire (HAQ) and laboratory data were collected and compared among different RA groups. Results: 5268 RA patients with mean age of 44.9±11.6 years, and 4477 (85%) were females. 2900 (55%) had DPRA, 892 (16.9%) had single positive RF, 597 (11.3%) had single positive anti-CCP while 879 (16.7%) had DNRA. Patients with DPRA had significantly high percentage of metabolic syndrome (19.3%, P < 0.001), and functional impairment using HAQ ( P = 0.01). Older age (RRR [relative risk ratio]: 1.03, 95%CI: 1.0, 1.0, P = 0.029), greater DAS28 (RRR: 1.51, 95%CI: 1.2, 1.9, P < 0.001), higher steroid use (RRR: 2.4, 95%CI: 1.36, 4.25, P = 0.002) were at higher risk of DPRA while longer disease duration (RRR: 1.08, 95%CI: 1.01, 1.16, P = 0.017) and fibromyalgia syndrome (RRR: 2.54, 95%CI: 1.10, 5.88, P = 0.028) were associated with higher odds of single positive RF status. Conclusion: Dual antibody-positive status has higher disease activity and severity, and higher chance of development of metabolic syndrome; highlighting the implicated role of inflammation, atherogenesis and cardiovascular disease risk in RA. Competing Interests: Conflict of Interest The authors declare no conflict of interest. (© 2024 Nevin Hammam, Passant N. El-Husseiny, Suzan S. Al-Adle, Nermeen Samy, Nora Y. Elsaid, Dina F. El-Essawi, Eman F. Mohamed, Samar M. Fawzy, Samah A. El Bakry, Maha Nassr, Samah I. Nasef, Hanan M. El-Saadany, Shereen Elwan, Nada M. Gamal, Abdelhfeez Moshrif, Osman Hammam, Rawhya R. El Shereef, Faten Ismail, Samar Tharwat, Doaa Mosad Mosa, Mervat I Abd Elazeem, Enas A. Abdelaleem, Tamer A. Gheita; on behalf of The Egyptian College of Rheumatology (ECR) Rheumatoid Arthritis (ECR-RA) Study Group, published by De Gruyter on behalf of NCRC-DID.)
Databáze:	MEDLINE
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