Acute Pancreatitis Induced by COVID-19 Vaccine: A Systematic Review.

Autor:	Hussain A; Internal Medicine, Appalachian Regional Health, Harlan, USA., Augustine SW; Internal Medicine, Liaquat University of Medical and Health Sciences, Hyderabad, PAK., Pyakurel S; Internal Medicine, University of Science and Technology Chittagong, Chittagong, BGD., Vempalli H; Internal Medicine, Narayana Medical College, Nellore, IND., Dabbara R; Internal Medicine, Kamineni Institute of Medical Sciences, Hyderabad, IND., O'dare RA; Nursing, South University, Savannah, USA.; General Medicine, Medical University of Graz, Graz, AUT., Ayush; Internal Medicine, National Capital Region Institute of Medical Sciences, Meerut, IND., Varghese JJ; Internal Medicine, Government Medical College & Hospital, Thiruvananthapuram, IND., Inban P; General Medicine, Government Medical College, Omandurar Government Estate, Chennai, IND., Jayan M; Internal Medicine, Bangalore Medical College and Research Institute, Bangalore, IND., Osigwe EC; Internal Medicine, Hayat Medical College Undergraduate, Addis Ababa, ETH., Sunkara SM; Obstetrics and Gynecology, Caribbean Medical University, Willemstad, CUW., Khan A; Trauma Surgery, OSF Healthcare Hospital, University of Illinois College of Medicine, Peoria, USA.; Internal Medicine, Lala Lajpat Rai (LLR) Hospital, Kanpur, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Mar 03; Vol. 16 (3), pp. e55426. Date of Electronic Publication: 2024 Mar 03 (Print Publication: 2024).
DOI:	10.7759/cureus.55426
Abstrakt:	Acute pancreatitis, marked by sudden inflammation of the pancreas, presents a complex spectrum of causative factors including gallstone obstruction, alcohol abuse, and viral infections. Recent studies have illuminated the emergence of vaccine-induced acute pancreatitis, notably associated with COVID-19 vaccinations, presenting diverse mechanisms ranging from direct viral-mediated injury to autoimmune reactions. Understanding this link is pivotal for public health, yet challenges persist in identifying and managing cases post-vaccination. Comprehensive literature reviews employing the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement outline the potential pathways and mechanisms leading to vaccine-induced pancreatitis, emphasizing the need for deeper investigations into underlying health conditions and modifications to vaccine components. Notably, the rare occurrences of vaccine-induced pancreatitis extend beyond COVID-19 vaccines, with reports also documenting associations with measles, mumps, and rubella (MMR), human papillomavirus (HPV), and other viral vaccinations. Mechanistically, hypotheses such as molecular mimicry and immunologic injury have been proposed, necessitating ongoing vigilance and exploration. Regulatory agencies play a crucial role in monitoring and communicating vaccine safety concerns, emphasizing transparency to address potential risks and maintain public trust. Understanding and communicating these rare adverse events with transparency remain integral for informed vaccination policies and to allay concerns surrounding vaccine safety. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Hussain et al.)
Databáze:	MEDLINE
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