The Relationship of Pathological Response and Visceral Muscle and Fat Volume in Women With Breast Cancer Who Received Neoadjuvant Chemotherapy.

Autor:	Kayan Tapan T; Department of Nutrition and Dietetic, Demiroğlu Bilim University Faculty of Health Sciences, İstanbul, Turkey., Çelebi F; Department of Radiology, Yeditepe University Faculty of Medicine, İstanbul, Turkey., Yaghouti K; Clinic of Radiology, Gayrettepe Florance Nightingale Hospital, İstanbul, Turkey., Ağaçayak F; Clinic of Radiology, İstanbul Florance Nightingale Hospital, İstanbul, Turkey., İlgün S; Clinic of Breast Surgeon, Mater Dei Hospital, Central Region, Malta., Soybir G; Clinic of General Surgeon, Şişli Memorial Hospital, İstanbul, Turkey., Alço G; Clinic of Radiation Oncology, Gayrettepe Florance Nightingale Hospital, İstanbul, Turkey., Ak N; Clinic of Oncology, Gayrettepe Florance Nightingale Hospital, İstanbul, Turkey., Ordu Ç; Clinic of Oncology, Gayrettepe Florance Nightingale Hospital, İstanbul, Turkey., Özkurt E; Clinic of Breast Surgeon, İstanbul Florance Nightingale Hospital, İstanbul, Turkey., Ünal Ç; Clinic of Oncology, Kartal Dr. Lütfi Kırdar City Hospital, İstanbul, Turkey., Kurt S; Clinic of Plastic Surgeon, Gayrettepe Florance Nightingale Hospital, İstanbul, Turkey., Öztürk A; Department of General Surgeon, Biruni University Hospital, Biruni University Faculty of Medicine, İstanbul, Turkey., İyigün Z; Department of Physical Therapy and Rehabilitation, Göztepe Medicalpark Hospital, Bahçeşehir University Faculty of Medicine, İstanbul, Turkey., Duymaz T; Department of Physical Therapy and Rehabilitation, İstanbul Bilgi University Faculty of Health Sciences, İstanbul, Turkey., Özmen V; Department of General Surgery, Breast Surgery, Surgical Oncology, İstanbul University-İstanbul Faculty of Medicine, İstanbul, Turkey.
Jazyk:	angličtina
Zdroj:	European journal of breast health [Eur J Breast Health] 2024 Apr 01; Vol. 20 (2), pp. 117-121. Date of Electronic Publication: 2024 Apr 01 (Print Publication: 2024).
DOI:	10.4274/ejbh.galenos.2024.2023-12-5
Abstrakt:	Objective: Differences in individual muscle/fat volumes may change the effectiveness of chemotherapy. In this study, the relationship between trunkal muscle and fat volume and body mass index (BMI) obtained before receiving neoadjuvant chemotherapy (NCT) in patients with breast cancer and complete pathological response (pCR) was investigated. Materials and Methods: The volumes of psoas, abdominal and paraspinal muscles, and trunkal subcutaneous and visceral fat were calculated using CoreSlicer AI 2.0 opensource program from the F-18 fluorodeoxyglucose positron emission tomography/computed tomography (CT) and CT images before NCT and postoperative pCR rates to NCT were recorded. Muscle/fat volumes and BMI prior to NCT were compared in terms of pathological pCR rates. Patients were followed up regularly for recurrence and survival. Results: Ninety-three patients were included with median (range) values for age, BMI, and body weights of 48 (28-72) years, 27 (16.8-51.6) kg/m 2 , and 71.94 (43-137) kg, respectively. The median follow-up time was 18.6 (6.7-59.6) months. No significant correlation was found between total muscle or fat volumes of patients with and without pCR. BMI [26.2 (16.8-51.6) kg/m 2 vs . 24.6 (20.3-34.3) kg/m 2 , p = 0.03] and pCR rates in patients with low right-psoas muscle volume [11.74 (7.03-18.51) vs . 10.2 (6.71-13.36), p = 0.025] were significantly greater. A significant relationship was found between right psoas muscle volume and disease-free survival (DFS) (11.74 cm 3 (7.03-18.51) vs . 10.2 cm 3 (6.71-13.36), p = 0.025). However, no significant relationship was detected between total muscle-fat volume, BMI and overall survival and DFS ( p >0.05). Conclusion: This is the first published study investigating the relationship between the pCR ratio and body muscle and fat volume measured by CoreSlicer AI 2.0 in patients with breast cancer who received NCT. No correlation was found between the pCR ratio and total muscle plus fat volume. However, these results need to be validated with larger patient series. Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare. (©Copyright 2024 by the Turkish Federation of Breast Diseases Societies / European Journal of Breast Health published by Galenos Publishing House.)
Databáze:	MEDLINE
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