Longitudinal dynamics of farmer and livestock nasal and faecal microbiomes and resistomes.

Autor: Mahmud B; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Vargas RC; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Sukhum KV; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St Louis, MO, USA., Patel S; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St Louis, MO, USA., Liao J; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St Louis, MO, USA., Hall LR; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Kesaraju A; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Le T; Integrated Research Development Laboratory, Marshfield Clinic Research Institute, Marshfield, WI, USA., Kitchner T; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, USA., Kronholm E; Center for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, WI, USA., Koshalek K; National Farm Medicine Center, Marshfield Clinic Research Institute, Marshfield, WI, USA., Bendixsen CG; National Farm Medicine Center, Marshfield Clinic Research Institute, Marshfield, WI, USA., VanWormer JJ; Center for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, WI, USA., Shukla SK; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, USA. shukla.sanjay@marshfieldresearch.org.; Computational Informatics in Biology and Medicine program, University of Wisconsin-Madison, Madison, WI, USA. shukla.sanjay@marshfieldresearch.org.; Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI, USA. shukla.sanjay@marshfieldresearch.org., Dantas G; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA. dantas@wustl.edu.; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St Louis, MO, USA. dantas@wustl.edu.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. dantas@wustl.edu.; Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO, USA. dantas@wustl.edu.; Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA. dantas@wustl.edu.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2024 Apr; Vol. 9 (4), pp. 1007-1020. Date of Electronic Publication: 2024 Apr 03.
DOI: 10.1038/s41564-024-01639-4
Abstrakt: Globally, half a billion people are employed in animal agriculture and are directly exposed to the associated microorganisms. However, the extent to which such exposures affect resident human microbiomes is unclear. Here we conducted a longitudinal profiling of the nasal and faecal microbiomes of 66 dairy farmers and 166 dairy cows over a year-long period. We compare farmer microbiomes to those of 60 age-, sex- and ZIP code-matched people with no occupational exposures to farm animals (non-farmers). We show that farming is associated with microbiomes containing livestock-associated microbes; this is most apparent in the nasal bacterial community, with farmers harbouring a richer and more diverse nasal community than non-farmers. Similarly, in the gut microbial communities, we identify more shared microbial lineages between cows and farmers from the same farms. Additionally, we find that shared microbes are associated with antibiotic resistance genes. Overall, our study demonstrates the interconnectedness of human and animal microbiomes.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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