Monte carlo simulation study on the dose and dose-averaged linear energy transfer distributions in carbon ion radiotherapy.

Autor: Ishikawa A; Nuclear Science and Engineering Center, Japan Atomic Energy Agency, 2-4 Shirakata, Tokai-mura, Ibaraki, 319-1195, Japan. ishikawa.akihisa@jaea.go.jp.; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba, 263-8555, Japan. ishikawa.akihisa@jaea.go.jp.; Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8603, Japan. ishikawa.akihisa@jaea.go.jp., Koba Y; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba, 263-8555, Japan., Furuta T; Nuclear Science and Engineering Center, Japan Atomic Energy Agency, 2-4 Shirakata, Tokai-mura, Ibaraki, 319-1195, Japan., Chang W; Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashiogu, Arakawa-Ku, Tokyo, 116-8551, Japan., Yonai S; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba, 263-8555, Japan., Matsumoto S; Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashiogu, Arakawa-Ku, Tokyo, 116-8551, Japan., Hashimoto S; Nuclear Science and Engineering Center, Japan Atomic Energy Agency, 2-4 Shirakata, Tokai-mura, Ibaraki, 319-1195, Japan., Hirai Y; Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashiogu, Arakawa-Ku, Tokyo, 116-8551, Japan., Sato T; Nuclear Science and Engineering Center, Japan Atomic Energy Agency, 2-4 Shirakata, Tokai-mura, Ibaraki, 319-1195, Japan.
Jazyk: angličtina
Zdroj: Radiological physics and technology [Radiol Phys Technol] 2024 Jun; Vol. 17 (2), pp. 553-560. Date of Electronic Publication: 2024 Apr 03.
DOI: 10.1007/s12194-024-00798-7
Abstrakt: Dose-averaged linear energy transfer (LET d ) is conventionally evaluated from the relative biological effectiveness (RBE)-LET d fitted function used in the treatment planning system. In this study, we calculated the physical doses and their linear energy transfer (LET) distributions for patterns of typical CIRT beams using Monte Carlo (MC) simulation. The LET d was then deduced from the MC simulation and compared with that obtained from the conventional method. The two types of LET d agreed well with each other, except around the distal end of the spread-out Bragg peak. Furthermore, an MC simulation was conducted with the material composition of water and realistic materials. The profiles of physical dose and LET d were in good agreement for both techniques. These results indicate that the previous studies to analyze the minimum LET d in CIRT cases are valid for practical situations, and the material composition conversion to water little affects the dose distribution in the irradiation field.
(© 2024. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.)
Databáze: MEDLINE
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