Transformation of Motion Pattern Selectivity from Retina to Superior Colliculus.

Autor:	DePiero VJ; Department of Biology, University of Virginia, Charlottesville, Virginia 22904.; Department of Psychology, University of Virginia, Charlottesville, Virginia 22904., Deng Z; Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637., Chen C; Department of Psychology, University of Virginia, Charlottesville, Virginia 22904., Savier EL; Department of Biology, University of Virginia, Charlottesville, Virginia 22904.; Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109., Chen H; Department of Biology, University of Virginia, Charlottesville, Virginia 22904.; Department of Psychology, University of Virginia, Charlottesville, Virginia 22904., Wei W; Department of Neurobiology, Neuroscience Institute, University of Chicago, Chicago, Illinois 60637 cang@virginia.edu weiw@uchicago.edu., Cang J; Department of Biology, University of Virginia, Charlottesville, Virginia 22904 cang@virginia.edu weiw@uchicago.edu.; Department of Psychology, University of Virginia, Charlottesville, Virginia 22904.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 May 15; Vol. 44 (20). Date of Electronic Publication: 2024 May 15.
DOI:	10.1523/JNEUROSCI.1704-23.2024
Abstrakt:	The superior colliculus (SC) is a prominent and conserved visual center in all vertebrates. In mice, the most superficial lamina of the SC is enriched with neurons that are selective for the moving direction of visual stimuli. Here, we study how these direction selective neurons respond to complex motion patterns known as plaids, using two-photon calcium imaging in awake male and female mice. The plaid pattern consists of two superimposed sinusoidal gratings moving in different directions, giving an apparent pattern direction that lies between the directions of the two component gratings. Most direction selective neurons in the mouse SC respond robustly to the plaids and show a high selectivity for the moving direction of the plaid pattern but not of its components. Pattern motion selectivity is seen in both excitatory and inhibitory SC neurons and is especially prevalent in response to plaids with large cross angles between the two component gratings. However, retinal inputs to the SC are ambiguous in their selectivity to pattern versus component motion. Modeling suggests that pattern motion selectivity in the SC can arise from a nonlinear transformation of converging retinal inputs. In contrast, the prevalence of pattern motion selective neurons is not seen in the primary visual cortex (V1). These results demonstrate an interesting difference between the SC and V1 in motion processing and reveal the SC as an important site for encoding pattern motion. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 the authors.)
Databáze:	MEDLINE
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