TNF-α: A serological marker for evaluating the severity of hippocampal sclerosis in medial temporal lobe epilepsy?
| Autor: | Wang B; Department of Neurology, Suining County People's Hospital, Affiliated Hospital of Xuzhou Medical University, China., Li Q; Department of Neurology, Affiliated Hospital of Xuzhou Medical University, China., Wang H; Department of Neurology, Affiliated Hospital of Xuzhou Medical University, China., Du X; Department of Neurology, Xuzhou Municipal Hospital, China., Lai Q; Department of Neurology, Affiliated Hospital of Xuzhou Medical University, China., Li X; Department of Neurology, Affiliated Hospital of Xuzhou Medical University, China., Wang Y; Department of Neurology, Affiliated Huaihai Hospital of Xuzhou Medical University, China., Hu P; Department of Neurology, Affiliated Hospital of Xuzhou Medical University, China., Fan H; Department of Neurology, Affiliated Hospital of Xuzhou Medical University, China. Electronic address: fandoc@126.com. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2024 May; Vol. 123, pp. 123-129. Date of Electronic Publication: 2024 Apr 02. |
| DOI: | 10.1016/j.jocn.2024.03.030 |
| Abstrakt: | Objective: By analysing the difference in TNF-α levels in the peripheral blood of patients with medial temporal lobe epilepsy (mTLE) with or without hippocampal sclerosis and the correlation between TNF-α and N-acetylaspartate levels in the hippocampus, we explored the relationship between TNF-α and the degree of damage to hippocampal sclerosis neurons in medial temporal lobe epilepsy. Methods: This is a prospective, population-based study. A total of 71 Patients with medial temporal lobe epilepsy diagnosed by clinical seizures, video-EEG, epileptic sequence MRI, and other imaging examinations were recruited from October 2020 to July 2022 in the Department of Neurology, Affiliated Hospital of Xuzhou Medical University. Twenty age-matched healthy subjects were selected as the control group. The patients were divided into two groups: the medial temporal epilepsy with hippocampal sclerosis group (positive group, mTLE-HS-P group) and the medial temporal epilepsy without hippocampal sclerosis group (negative group, mTLE-HS-N group). The levels of IL-1β, IL-5, IL-6, IL-8, IL-17, IFN-γ and TNF-α in the peripheral blood of the patients in the three groups were detected by multimicrosphere flow immunofluorescence assay. The level of N-acetylaspartate (NAA) in the hippocampus was measured by 1 H-MRS. The differences in cytokine levels among the three groups were analysed, and the correlation between cytokine and NAA levels was analysed. Results: The level of TNF-α in the peripheral blood of the patients in the mTLE-HS-P group was significantly higher than that of the patients in the mTLE-HS-N and healthy control groups, and the level of TNF-α in the patients in the mTLE-HS-N group was significantly higher than that of the patients in the healthy control group. The NAA level in mTLE-HS-P group patients was significantly lower than that of mTLE-HS-N patients and healthy controls, but there was no significant difference between mTLE-HS-N patients and healthy controls (P > 0.05). Spearman correlation analysis showed that TNF-α level (r Conclusion: The level of TNF-α in the peripheral blood of patients with medial temporal lobe epilepsy with hippocampal sclerosis was higher, and it was correlated with NAA and hippocampal sclerosis. The high expression of TNF-α may be of important value in the evaluation of hippocampal sclerosis patients. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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