| Autor: |
Abd-Elsayed A; Department of Anesthesiology, University of WI School of Medicine and Public Health, Madison, WI, USA., Stark CW; Department of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA., Topoluk N; Department of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA., Isaamullah M; Department of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA., Uzodinma P; Department of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA., Viswanath O; Anesthesiology, LSU Health Sciences Center School of Medicine, New Orleans, LA, USA., Gyorfi MJ; Department of Anesthesiology, University of WI School of Medicine and Public Health, Madison, WI, USA., Fattouh O; Department of Neurobiology, University of Wisconsin-Madison, Madison, WI, USA., Schlidt KC; Department of Surgery, Sinai Hospital of Baltimore, Baltimore, MD, USA., Dyara O; Department of Anesthesiology, Medical College of Wisconsin, Wauwatosa, WI, USA. |
| Abstrakt: |
Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition that, although exceedingly rare, carries a significant burden for the affected patient population. The complex and ambiguous pathophysiology of this condition further complicates clinical management and therapeutic interventions. Furthermore, being a diagnosis of exclusion requires a diligent workup to ensure an accurate diagnosis and subsequent targeted management. The development of the Budapest diagnostic criteria helped to consolidate existing definitions of CRPS but extensive work remains in identifying the underlying pathways. Currently, two distinct types are identified by the presence (CRPS type 1) or absence (CRPS type 2) of neuronal injury. Current management directed at this disease is broad and growing, ranging from non-invasive modalities such as physical and psychological therapy to more invasive techniques such as dorsal root ganglion stimulation and potentially amputation. Ideal therapeutic interventions are multimodal in nature to address the likely multifactorial pathological development of CRPS. Regardless, a significant need remains for continued studies to elucidate the pathways involved in developing CRPS as well as more robust clinical trials for various treatment modalities. |
