Butyric acid and prospects for creation of new medicines based on its derivatives: a literature review.

Autor:	Gerunova LK; Department of Pharmacology and Toxicology, Omsk State Agrarian University named after P. A. Stolypin, Omsk 644008, Russian Federation., Gerunov TV; Department of Pharmacology and Toxicology, Omsk State Agrarian University named after P. A. Stolypin, Omsk 644008, Russian Federation., P'yanova LG; Department of Materials Science and Physicochemical Research Methods, Center of New Chemical Technologies BIC, Omsk 644040, Russian Federation., Lavrenov AV; Department of Materials Science and Physicochemical Research Methods, Center of New Chemical Technologies BIC, Omsk 644040, Russian Federation., Sedanova AV; Department of Materials Science and Physicochemical Research Methods, Center of New Chemical Technologies BIC, Omsk 644040, Russian Federation., Delyagina MS; Department of Materials Science and Physicochemical Research Methods, Center of New Chemical Technologies BIC, Omsk 644040, Russian Federation. medugli@mail.ru., Fedorov YN; Laboratory of Immunology, All-Russian Research and Technological Institute of Biological Industry, pos. Biokombinata, Shchelkovskii Region, Moscow Province 141142, Russian Federation., Kornienko NV; Department of Materials Science and Physicochemical Research Methods, Center of New Chemical Technologies BIC, Omsk 644040, Russian Federation., Kryuchek YO; Department of Pharmacology and Toxicology, Omsk State Agrarian University named after P. A. Stolypin, Omsk 644008, Russian Federation., Tarasenko AA; Department of Pharmacology and Toxicology, Omsk State Agrarian University named after P. A. Stolypin, Omsk 644008, Russian Federation.
Jazyk:	angličtina
Zdroj:	Journal of veterinary science [J Vet Sci] 2024 Mar; Vol. 25 (2), pp. e23.
DOI:	10.4142/jvs.23230
Abstrakt:	The widespread use of antimicrobials causes antibiotic resistance in bacteria. The use of butyric acid and its derivatives is an alternative tactic. This review summarizes the literature on the role of butyric acid in the body and provides further prospects for the clinical use of its derivatives and delivery methods to the animal body. Thus far, there is evidence confirming the vital role of butyric acid in the body and the effectiveness of its derivatives when used as animal medicines and growth stimulants. Butyric acid salts stimulate immunomodulatory activity by reducing microbial colonization of the intestine and suppressing inflammation. Extraintestinal effects occur against the background of hemoglobinopathy, hypercholesterolemia, insulin resistance, and cerebral ischemia. Butyric acid derivatives inhibit histone deacetylase. Aberrant histone deacetylase activity is associated with the development of certain types of cancer in humans. Feed additives containing butyric acid salts or tributyrin are used widely in animal husbandry. They improve the functional status of the intestine and accelerate animal growth and development. On the other hand, high concentrations of butyric acid stimulate the apoptosis of epithelial cells and disrupt the intestinal barrier function. This review highlights the biological activity and the mechanism of action of butyric acid, its salts, and esters, revealing their role in the treatment of various animal and human diseases. This paper also discussed the possibility of using butyric acid and its derivatives as surface modifiers of enterosorbents to obtain new drugs with bifunctional action. Competing Interests: The authors declare no conflicts of interest. (© 2024 The Korean Society of Veterinary Science.)
Databáze:	MEDLINE
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