Heat and Acupuncture to Manage Osteoarthritis of the Knee (HARMOKnee): Protocol for an Effectiveness-Implementation Hybrid Randomized Controlled Trial.

Autor:	Tan BY; Department of Orthopaedic Surgery, Woodlands Health, National Healthcare Group, Singapore, Singapore., Tan CY; Department of Orthopaedic Surgery, Woodlands Health, National Healthcare Group, Singapore, Singapore., Tan TL; Department of Orthopaedic Surgery, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore., Yang SY; Psychology Service, Woodlands Health, Singapore, Singapore., Chew GLS; Department of Orthopaedic Surgery, Woodlands Health, National Healthcare Group, Singapore, Singapore., Tan SI; Complementary Integrative Medicine, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore., Chua YC; Complementary Integrative Medicine, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore., Yan YW; Complementary Integrative Medicine, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore., Soh DBQ; Complementary Integrative Medicine, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore., Goh TH; Traditional Chinese Medicine Pain Management, Medical Department, Singapore Chung Hwa Medical Institution, Singapore, Singapore.; Teaching Department, Singapore College of Traditional Chinese Medicine, Singapore, Singapore., Ng PJ; Traditional Chinese Medicine Pain Management, Medical Department, Singapore Chung Hwa Medical Institution, Singapore, Singapore.; Teaching Department, Singapore College of Traditional Chinese Medicine, Singapore, Singapore., Ng YT; Traditional Chinese Medicine Pain Management, Medical Department, Singapore Chung Hwa Medical Institution, Singapore, Singapore., Kuan SB; Traditional Chinese Medicine Pain Management, Medical Department, Singapore Chung Hwa Medical Institution, Singapore, Singapore., Teo BS; Traditional Chinese Medicine Pain Management, Medical Department, Singapore Chung Hwa Medical Institution, Singapore, Singapore., Kong KH; Rehabilitation Centre, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore., Pereira MJ; Health Services and Outcomes Research, National Healthcare Group, Singapore, Singapore., Ng HP; Traditional Chinese Medicine Pain Management, Medical Department, Singapore Chung Hwa Medical Institution, Singapore, Singapore.; Teaching Department, Singapore College of Traditional Chinese Medicine, Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	JMIR research protocols [JMIR Res Protoc] 2024 Apr 03; Vol. 13, pp. e54352. Date of Electronic Publication: 2024 Apr 03.
DOI:	10.2196/54352
Abstrakt:	Background: Knee osteoarthritis (KOA) is one of most prevalent and fastest-growing causes of pain, impaired mobility, and poor quality of life in the rapidly aging population worldwide. There is a lack of high-quality evidence on the efficacy of traditional Chinese medicine (TCM), particularly acupuncture, and a lack of KOA practice guidelines that are tailored to unique population demographics and tropical climates. Objective: Our HARMOKnee (Heat and Acupuncture to Manage Osteoarthritis of the Knee) trial aims to address these gaps by evaluating the short- and medium-term clinical and cost-effectiveness of acupuncture with heat therapy in addition to standard care, compared to standard care alone. Through a robust process and economic evaluation, we aim to inform evidence-based practice for patients with KOA to facilitate the large-scale implementation of a comprehensive and holistic model of care that harmonizes elements of Western medicine and TCM. We hypothesize that acupuncture with heat therapy as an adjunct to standard care is clinically more effective than standard care alone. Methods: A multicenter, pragmatic, parallel-arm, single-blinded, effectiveness-implementation hybrid randomized controlled trial will be conducted. We intend to recruit 100 patients with KOA randomized to either the control arm (standard care only) or intervention arm (acupuncture with heat therapy, in addition to standard care). The inclusion criteria are being a community ambulator and having primary KOA, excluding patients with secondary arthritis or previous knee replacements. The primary outcome measure is the Knee Osteoarthritis Outcome Score at 6 weeks. Secondary outcome measures include psychological, physical, quality of life, satisfaction, and global outcome measures at 6, 12, and 26 weeks. A mixed method approach through an embedded process evaluation will facilitate large-scale implementation. An economic evaluation will be performed to assess financial sustainability. Results: Patient enrollment has been ongoing since August 2022. The recruitment process is anticipated to conclude by July 2024, and the findings will be analyzed and publicized as they are obtained. As of November 6, 2023, our patient enrollment stands at 65 individuals. Conclusions: The findings of our HARMOKnee study will contribute substantial evidence to the current body of literature regarding the effectiveness of acupuncture treatment for KOA. Additionally, we aim to facilitate the creation of standardized national guidelines for evidence-based practice that are specifically tailored to our unique population demographics. Furthermore, we seek to promote the adoption and integration of acupuncture and heat therapy into existing treatment models. Trial Registration: ClinicalTrials.gov NCT05507619; https://clinicaltrials.gov/study/NCT05507619. International Registered Report Identifier (irrid): DERR1-10.2196/54352. (©Bryan Yijia Tan, Chun Yue Tan, Tong Leng Tan, Su-Yin Yang, Gillian Long Szu Chew, Siang Ing Tan, Yu Chun Chua, Yew Wai Yan, Derrick Bing Quan Soh, Tong Hwee Goh, Pu Jue Ng, Yee Teck Ng, Swee Boey Kuan, Bo Siang Teo, Keng He Kong, Michelle Jessica Pereira, Hui Ping Ng. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 03.04.2024.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu