Parotid cancer: analysis of preoperative parameters for adaptation of the therapeutic strategy.

Autor: Ghenni S; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, LPL, Marseille, France. samia.ghenni@gmail.com., Del Grande J; Department of Anatomopathology, Centre Hospitalier Universitaire (CHU) la Timone, Assistance Publique-Hôpitaux de Marseille (AP-HM), Aix Marseille Univ, Marseille, France., Gravier Dumonceau R; APHM, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Aix Marseille Univ, Marseille, France., Haddad R; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, LPL, Marseille, France., Giorgi R; APHM, INSERM, IRD, SESSTIM, Sciences Économiques & Sociales de la Santé & Traitement de l'Information Médicale, Hop Timone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Aix Marseille Univ, Marseille, France., Michel J; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, LPL, Marseille, France.; APHM, CNRS, IUSTI, La Conception University Hospital, ENT-HNS Department, Aix Marseille Univ, Marseille, France., Fernandez R; Department of Radiology, Centre Hospitalier Universitaire (CHU) la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Aix Marseille Univ, Marseille, France., Fakhry N; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, AP-HM, Aix Marseille Univ, LPL, Marseille, France. Nicolas.fakhry@ap-hm.fr.
Jazyk: angličtina
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2024 Jun; Vol. 281 (6), pp. 3207-3218. Date of Electronic Publication: 2024 Apr 03.
DOI: 10.1007/s00405-024-08607-y
Abstrakt: Purpose: To establish typical clinical and radiological profiles of primary low-grade parotid cancers in order to tailor therapeutic strategy.
Materials and Methods: Retrospective study of 57 patients operated on for primary parotid cancer between 2010 and 2021, with review of preoperative MRI and histopathology according to a standardized scoring grid.
Objective: To study prognostic factors and determine the preoperative clinical and radiological profile of low-grade cancers.
Results: Good prognostic factors for specific survival were: staging ≤ cT3 (p = 0.014), absence of adenopathy on cN0 MRI (p < 0.001), superficial lobe location (p = 0.033), pN0 (p < 0.001), absence of capsular rupture (p = 0.004), as well as the absence of peri-tumoral nodules (p = 0.033), intra-parotid adenopathies (p < 0.001), vascular emboli (p < 0.001), peri-neural sheathing (p = 0.016), nuclear atypia (p = 0.031), and necrosis (p = 0.002). It was not possible to define a reliable clinical and radiological profile for low-grade cancers (sensitivity 38%, specificity 79%).
Conclusion: Our study demonstrated multiple factors of good prognosis, but it was not possible to define a clinical and radiological profile of patients likely to benefit from more limited surgery, nor to diagnose, a priori, low-grade cancers.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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