Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection.

Autor:	Goguet E; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Olsen CH; Department of Preventive Medicine & Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Meyer WA 3rd; Quest Diagnostics, Secaucus, NJ, United States., Ansari S; Quest Diagnostics, Secaucus, NJ, United States., Powers JH 3rd; Clinical Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States., Conner TL; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Coggins SA; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Wang W; Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States., Wang R; Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States., Illinik L; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Sanchez Edwards M; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Jackson-Thompson BM; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Hollis-Perry M; Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, United States., Wang G; Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, United States.; General Dynamics Information Technology, Falls Church, VA, United States., Alcorta Y; Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, United States.; General Dynamics Information Technology, Falls Church, VA, United States., Wong MA; Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, United States.; General Dynamics Information Technology, Falls Church, VA, United States., Saunders D; Translational Medicine Unit, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Mohammed R; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Balogun B; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Kobi P; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Kosh L; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Bishop-Lilly K; Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States., Cer RZ; Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States., Arnold CE; Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States.; Defense Threat Reduction Agency, Fort Belvoir, VA, United States., Voegtly LJ; Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States.; Leidos, Reston, VA, United States., Fitzpatrick M; Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States.; Leidos, Reston, VA, United States., Luquette AE; Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States.; Leidos, Reston, VA, United States., Malagon F; Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, MD, United States.; Leidos, Reston, VA, United States., Ortega O; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Parmelee E; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Davies J; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Lindrose AR; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Haines-Hull H; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Moser MS; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Samuels EC; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Rekedal MS; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Graydon EK; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States., Malloy AMW; Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Tribble DR; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Burgess TH; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Campbell W; Division of Infectious Diseases, Walter Reed National Military Medical Center, Bethesda, MD, United States., Robinson S; Division of Infectious Diseases, Walter Reed National Military Medical Center, Bethesda, MD, United States., Broder CC; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., O'Connell RJ; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Weiss CD; Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States., Pollett S; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Laing ED; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Mitre E; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Mar 19; Vol. 15, pp. 1287504. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1287504
Abstrakt:	Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States. Methods: Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires. Results: Serum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk scores correlated with protection against PVIs after multivariable regression analysis. Commercial assays did not perform as well as research assay, likely due to their lower dynamic range. Discussion: In the 32 participants that developed PVI, anti-Spike IgG bAbs correlated with lower disease severity and shorter duration of illness. Competing Interests: SP, TB, and DT report that the USU IDCRP, a U.S. Department of Defense DoD Institution, and the HJF were funded under a Cooperative Research and Development Agreement to conduct an unrelated phase III COVID-19 monoclonal antibody immunoprophylaxis trial sponsored by AstraZeneca. The HJF, in support of the USU IDCRP, was funded by the DoD Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense to augment the conduct of an unrelated phase III vaccine trial sponsored by AstraZeneca. Both trials were part of the USG COVID-19 response. Neither is related to the work presented here. Authors WM and SA were employed by the company Quest Diagnostics. Author JP was employed by company Leidos Biomedical Research, Inc. Authors LV, MF, AL and FM were employed by company Leidos. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Goguet, Olsen, Meyer, Ansari, Powers, Conner, Coggins, Wang, Wang, Illinik, Sanchez Edwards, Jackson-Thompson, Hollis-Perry, Wang, Alcorta, Wong, Saunders, Mohammed, Balogun, Kobi, Kosh, Bishop-Lilly, Cer, Arnold, Voegtly, Fitzpatrick, Luquette, Malagon, Ortega, Parmelee, Davies, Lindrose, Haines-Hull, Moser, Samuels, Rekedal, Graydon, Malloy, Tribble, Burgess, Campbell, Robinson, Broder, O’Connell, Weiss, Pollett, Laing and Mitre.)
Databáze:	MEDLINE
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