Role of Calprotectin, IL-6, and CRP in Distinguishing Between Inflammatory Bowel Disease and Diarrhea Predominant Irritable Bowel Syndrome.

Autor:	Huong BT; Department of Biochemistry, Thai Nguyen University of Medicine and Pharmacy (TUMP), Thai Nguyen, Vietnam., Hien NM; Department of Biochemistry, Thanh Nhan Hospital, Hanoi, Vietnam., Dung NT; Department of Internal medicine, Thai Nguyen University of Medicine and Pharmacy (TUMP), Thai Nguyen, Vietnam., Quang DM; Department of Oncology, Thanh Nhan Hospital, Hanoi, Vietnam., Vinh NT; Department of Oncology, Thanh Nhan Hospital, Hanoi, Vietnam., Tu TT; Department of Oncology, Thanh Nhan Hospital, Hanoi, Vietnam., Chi TK; Department of Biochemistry, Ha Noi Medical University, Ha Noi, Vietnam., Phuong LB; Department of Internal medicine, Van Hanh General Hospital, Ho Chi Minh City, Vietnam., Nhan NT; Medical Laboratory Faculty, Nguyen Tat Thanh University, Ho Chi Minh, Vietnam.
Jazyk:	angličtina
Zdroj:	Medical archives (Sarajevo, Bosnia and Herzegovina) [Med Arch] 2024; Vol. 78 (2), pp. 105-111.
DOI:	10.5455/medarh.2024.78.105-111
Abstrakt:	Background: The early establishment of prophylaxis and immediate administration of anticoagulant therapy upon the diagnosis of venous thromboembolism should be the treatment objectives in these patients. Objective: The study aimed to determine the optimal cut-off point of Calprotectin, IL-6 (interleukin-6), CRP (C reactive protein) to differentiate UC, IBS-D. Methods: A cross-sectional descriptive study of 335 individuals ≥15 years old was performed, including 31 healthy controls, 215 with IBS-D, 71 diagnosed with UC, and 18 diagnosed with CD. Receiver Operating Characteristics (ROC), sensitivity, specificity, and area under curve (AUC) were computed. Results: The results showed that the median value of calprotectin (IQR) in healthy participants was 20.0 (6.0 - 34.0) µg/g; 17,7 (8,7-38,9) µg/g in IBS-D group; 1710.0 (588 - 4260,0) µg/g in UC group; and 560.5 (177.8 - 1210.0) µg/g in CD group. Calprotectin concentration in IBD group including UC and CD was higher than IBS-D with p<0.05. The median value of CRP (range IQR) was 1,3 (0,9 - 2,3) mg/L in IBS-D group; 7.0 (2.4 -16.6) mg/L in UC group; and 10.1 (2.2 - 42.5) mg/L in CD group. CRP concentration in IBD group including UC and CD was higher than IBS-D with p<0.05. The median value of IL-6 (range IQR) was 2.3 (1.6 - 5.7) pg/mL in IBS-D group; 16.8 (9.4 - 47.0) pg/mL in UC group; and 9.4 (7.9 - 11.0) pg/mL in CD group. Calprotectin concentration in IBD group including UC and CD was higher than IBS-D with p<0.05. The optimal cut-off point of calprotectin that differentiated IBS-D from IBD was 110.5 µg/g, with sensitivity and specificity of 93.3% and 91.4%, respectively; of IL-6 was 7.2 pg/mL with sensitivity and specificity of 92.0% and 78.0%, respectively; of CRP of 2.4 mg/L had specific sensitivities of 83.3% and 86.0%, respectively. Conclusion: The Calprotectin immunoassay has the best value in discriminating between IBD and IBS-D. Competing Interests: There are no conflicts of interest. (© 2024 Bui-Thi Thu Huong,, Nguyen Minh Hien, Nguyen Tien Dung*, Dao Minh Quang, Nguyen Thanh Vinh, Tran Thanh Tu, Tran Khanh Chi, Le-Thi Bich Phuong, Nguyen-Thi Nhan.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu