Skull Base Osteomyelitis- Marauders of the Skull.

Autor: Krishnakumar L; Department of ENT, Government Medical College, Thiruvananthapuram, Kerala 695011 India., Vinayakumar V; Department of ENT, Government Medical College, Thiruvananthapuram, Kerala 695011 India., Suchit Roy BR; Department of ENT, Government Medical College, Thiruvananthapuram, Kerala 695011 India., Gopalan M; Department of ENT, Government Medical College, Thiruvananthapuram, Kerala 695011 India., Venugopal M; Department of ENT, Government Medical College, Thiruvananthapuram, Kerala 695011 India.
Jazyk: angličtina
Zdroj: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India [Indian J Otolaryngol Head Neck Surg] 2024 Apr; Vol. 76 (2), pp. 1770-1774. Date of Electronic Publication: 2023 Dec 14.
DOI: 10.1007/s12070-023-04405-w
Abstrakt: Skull base osteomyelitis is a vicious infection of temporal bone associated with very high morbidity and mortality. But few studies have been undertaken recently for eliciting its increasing incidence. Hence this study aims to describe the clinical profile of skull base osteomyelitis and changes noted in the post-covid period, and encourage a uniform treatment policy globally. This descriptive study was conducted among 140 patients diagnosed with skull base osteomyelitis. Data was collected using semi-structured proforma, HRCT temporal bone findings, microbiological reports, histopathology of granulation tissue, ESR and House-Brackmann grading. Male patients in 61-70 age group were most commonly affected and all patients had uncontrolled diabetes mellitus, usually presenting with nocturnal otalgia, ear canal granulation and cranial nerve palsy. Pseudomonas aeruginosa was the most common isolate followed by Staphylococcus aureus . Among fungal pathogens, candida albicans were the most common. 29.3% patients had extensive disease according to Thakar et al. staging and on follow up, 43.75% patients showed a satisfactory response. Coronary artery disease and cerebrovascular accidents were the leading cause of death. More atypical organisms, extensive disease and changes in antibiotic sensitivity were noted in the post-covid period. Prolonged treatment with culture sensitive antibiotic is the main stay of treatment. A uniform treatment guideline is needed for proper management of such patients. Level of Evidence 4.
Competing Interests: Conflicts of interestThe authors bear no conflicts of interest.
(© Association of Otolaryngologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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