Aging and intraocular pressure homeostasis in mice.

Autor: Li G; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., van Batenburg-Sherwood J; Department of Bioengineering, Imperial College London, London, UK., Safa BN; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Fraticelli Guzmán NS; Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Wilson A; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Bahrani Fard MR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Choy K; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA., de Ieso ML; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Cui JS; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Feola AJ; Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.; Center for Visual and Neurocognitive Rehabilitation, Atlanta Virginia Medical Center, Decatur, Georgia, USA., Weisz T; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Kuhn M; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Bowes Rickman C; Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Farsiu S; Department of Ophthalmology, Duke University, Durham, North Carolina, USA.; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA., Ethier CR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.; Department of Ophthalmology, Emory University, Atlanta, Georgia, USA., Stamer WD; Department of Ophthalmology, Duke University, Durham, North Carolina, USA.; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Jazyk: angličtina
Zdroj: Aging cell [Aging Cell] 2024 Jul; Vol. 23 (7), pp. e14160. Date of Electronic Publication: 2024 Apr 02.
DOI: 10.1111/acel.14160
Abstrakt: Age and elevated intraocular pressure (IOP) are the two primary risk factors for glaucoma, an optic neuropathy that is the leading cause of irreversible blindness. In most people, IOP is tightly regulated over a lifetime by the conventional outflow tissues. However, the mechanistic contributions of age to conventional outflow dysregulation, elevated IOP and glaucoma are unknown. To address this gap in knowledge, we studied how age affects the morphology, biomechanical properties and function of conventional outflow tissues in C57BL/6 mice, which have an outflow system similar to humans. As reported in humans, we observed that IOP in mice was maintained within a tight range over their lifespan. Remarkably, despite a constellation of age-related changes to the conventional outflow tissues that would be expected to hinder aqueous drainage and impair homeostatic function (decreased cellularity, increased pigment accumulation, increased cellular senescence and increased stiffness), outflow facility, a measure of conventional outflow tissue fluid conductivity, was stable with age. We conclude that the murine conventional outflow system has significant functional reserve in healthy eyes. However, these age-related changes, when combined with other underlying factors, such as genetic susceptibility, are expected to increase risk for ocular hypertension and glaucoma.
(© 2024 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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