Illness-related outcomes of illicit substance use disorder in adolescents with early onset schizophrenia: a multicenter study.

Autor:	Turan S; Department of Child and Adolescent Psychiatry, Uludag University School of Medicine, Bursa, Turkey., Ermiş Ç; Sahlgrenska Universitetssjukhuset, Goteborg, Sweden., Eray Ş; Department of Child and Adolescent Psychiatry, Uludag University School of Medicine, Bursa, Turkey., Ağaç N; Department of Child and Adolescent Psychiatry, Uludag University School of Medicine, Bursa, Turkey., Karakuş OB; Department of Child and Adolescent Psychiatry, University of Health Sciences, Bakirkoy Prof Dr Mazhar Osman Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey., Sağlam Y; Department of Child and Adolescent Psychiatry, University of Health Sciences, Bakirkoy Prof Dr Mazhar Osman Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey., Bandırma A; Department of Child and Adolescent Psychiatry, Uludag University School of Medicine, Bursa, Turkey., Güler D; Department of Child and Adolescent Psychiatry, Dokuz Eylul University School of Medicine, İzmir, Turkey., Tunçtürk M; Department of Child and Adolescent Psychiatry, University of Health Sciences, Bakirkoy Prof Dr Mazhar Osman Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey., Çıray RO; Mardin State Hospital, Mardin, Turkey., Karaçetin G; Department of Child and Adolescent Psychiatry, University of Health Sciences, Bakirkoy Prof Dr Mazhar Osman Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey., İnal N; Department of Child and Adolescent Psychiatry, University of Health Sciences, Bakirkoy Prof Dr Mazhar Osman Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey., Üçok A; Department of Psychiatry, Psychotic Disorders Research Program, Istanbul Faculty of Medicine, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Journal of addictive diseases [J Addict Dis] 2024 Apr 02, pp. 1-5. Date of Electronic Publication: 2024 Apr 02.
DOI:	10.1080/10550887.2024.2332512
Abstrakt:	Objectives: Lifetime co-occurring substance use disorders are common at the time of presentation for the treatment of primary psychosis. Our aim was to investigate the clinical characteristics of adolescents with early-onset schizophrenia/schizoaffective disorder (EOS), categorized as either with (EOS + SUD) or without SUD (non-SUD/EOS), in a multi-center sample. Methods: Between 2016 and 2022, 255 patients were evaluated across three tertiary-care inpatient units. Diagnoses were confirmed by the treating physician according to the DSM-5 during the hospital stay. The severity of symptoms was measured using the Positive and Negative Syndrome Scale (PANSS). Results: The EOS + SUD group exhibited a higher illness onset, fewer years of education, longer duration of untreated psychosis (DUP), a higher frequency of male gender, more frequent hospitalizations, increased use of clozapine and zuclopenthixol LAI, along with higher rates of post-traumatic stress disorder and conduct disorder. Notably, differences in DUP, clozapine use, and the number of hospitalizations did not persist in the multivariate logistic regression model. Conclusions: Our findings support the notion of SUD playing a role in modifying the course of illness in EOS. Future studies should emphasize exploring treatment responses to medications and interventions among youth with dual diagnoses.
Databáze:	MEDLINE
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