Vitamin D metabolism in critically ill patients with acute kidney injury: a prospective observational study.
Autor: | Cameron LK; Department of Critical Care, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.; Pharmacy Department, Guy's and St Thomas' NHS Foundation Trust, London, UK.; Institute of Pharmaceutical Sciences, School of Cancer and Pharmacy, King's College London, London, SE1 9RT, UK., Ledwaba-Chapman L; Department of Population Health Sciences, King's College London, Addison House, Guy's Campus, London, SE1 1UL, UK., Voong K; Nutristasis Unit, Synnovis, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Hampson G; Department of Chemical Pathology and Metabolic Medicine, St Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK.; Department of Diabetes and Endocrinology, Metabolic Bone Clinic, St Thomas' Hospital, London, UK., Forni LG; Department of Critical Care, Royal Surrey Foundation Trust, Guildford, Surrey, UK.; School of Medicine, University of Surrey, Guildford, Surrey, UK., Seylanova N; Department of Critical Care, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK., Harrington DJ; Nutristasis Unit, Synnovis, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Lim R; Department of Critical Care, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK., Bociek A; Department of Critical Care, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK., Yanzhong W; Department of Population Health Sciences, King's College London, Addison House, Guy's Campus, London, SE1 1UL, UK., Ostermann M; Department of Critical Care, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK. marlies.ostermann@gstt.nhs.uk. |
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Jazyk: | angličtina |
Zdroj: | Critical care (London, England) [Crit Care] 2024 Apr 02; Vol. 28 (1), pp. 108. Date of Electronic Publication: 2024 Apr 02. |
DOI: | 10.1186/s13054-024-04869-4 |
Abstrakt: | Background: Vitamin D deficiency in critically ill patients is associated with poor outcomes, and vitamin D supplementation is recommended for patients with chronic kidney disease. Whether acute kidney injury (AKI) is associated with altered Vitamin D metabolism is unknown. We aimed to compare the longitudinal profiles of serum 25(OH)D and 1,25(OH) Methods: In this prospective, observational study in two centres in the UK, critically ill patients with and without AKI underwent serial measurement of serum 25(OH)D and 1,25(OH) Results: Serial data of 137 patients were analysed. Seventy-one patients had AKI stage II/III of whom 23 recovered kidney function during the 5-day study period; 66 patients did not have AKI at enrolment of whom 14 developed new AKI. On day of enrolment, patients' serum 25(OH)D concentrations were low (median 18 nmol/L) but there was no significant difference between patients with and without AKI. Median serum 1,25(OH) Conclusions: Critically ill patients with moderate-to-severe AKI have significantly lower serum 1,25(OH) (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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