Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma.

Autor: Yalcin F; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Institute of Pathology, Christian-Albrecht University of Kiel, Kiel, Germany.; Department of Neurosurgery, University Medical Center Schleswig-Holstein, Kiel, Germany., Haneke H; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Efe IE; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité Universitätsmedizin Berlin, Berlin, Germany., Kuhrt LD; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité Universitätsmedizin Berlin, Berlin, Germany., Motta E; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Nickl B; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Flüh C; Department of Neurosurgery, University Medical Center Schleswig-Holstein, Kiel, Germany., Synowitz M; Department of Neurosurgery, University Medical Center Schleswig-Holstein, Kiel, Germany., Dzaye O; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA., Bader M; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Charité Universitätsmedizin Berlin, Berlin, Germany.; Institute for Biology, University of Lübeck, Lübeck, Germany., Kettenmann H; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. kettenmann@mdc-berlin.de.; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. kettenmann@mdc-berlin.de.
Jazyk: angličtina
Zdroj: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Apr 02; Vol. 12 (1), pp. 50. Date of Electronic Publication: 2024 Apr 02.
DOI: 10.1186/s40478-024-01754-7
Abstrakt: Tumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and the murine RCAS-PDGFb high grade glioma model. Loss of GPNMB in the in vivo tumor microenvironment results in significantly smaller tumor volumes and generates a pro-inflammatory innate and adaptive immune cell microenvironment. The impact of host-derived GPNMB on tumor growth was confirmed in two distinct murine glioma cell lines in organotypic brain slices from GPNMB-KO and control mice. Using published data bases of human glioma, the elevated levels in TAMs could be confirmed and the GPNMB expression correlated with a poorer survival.
(© 2024. The Author(s).)
Databáze: MEDLINE
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