Phylogenetic analyses reveal insights into interdomain horizontal gene transfer of microbial lipases.

Autor: Medeiros P; Center for Natural Sciences and Humanities, Federal University of ABC, Santo André, SP, Brazil., Canato D; Center for Natural Sciences and Humanities, Federal University of ABC, Santo André, SP, Brazil., Braz ASK; Center for Natural Sciences and Humanities, Federal University of ABC, Santo André, SP, Brazil., Paulino LC; Center for Natural Sciences and Humanities, Federal University of ABC, Santo André, SP, Brazil. Electronic address: luciana.paulino@ufabc.edu.br.
Jazyk: angličtina
Zdroj: Molecular phylogenetics and evolution [Mol Phylogenet Evol] 2024 Jun; Vol. 195, pp. 108069. Date of Electronic Publication: 2024 Mar 31.
DOI: 10.1016/j.ympev.2024.108069
Abstrakt: Microbial lipases play a pivotal role in a wide range of biotechnological processes and in the human skin microbiome. However, their evolution remains poorly understood. Accessing the evolutionary process of lipases could contribute to future applications in health and biotechnology. We investigated genetic events associated with the evolutionary trajectory of the microbial family LIP lipases. Using phylogenetic analysis, we identified two distinct horizontal gene transfer (HGT) events from Bacteria to Fungi. Further analysis of human cutaneous mycobiome members such as the lipophilic Malassezia yeasts and CUG-Ser-1 clade (including Candida sp. and other microorganisms associated with cutaneous mycobiota) revealed recent evolutionary processes, with multiple gene duplication events. The Lid region of fungal lipases, crucial for substrate interaction, exhibits varying degrees of conservation among different groups. Our findings suggest the adaptability of the fungal LIP family in various genetic and metabolic contexts and its potential role in niche exploration.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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