The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex.

Autor: Makhani N; Department of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, New Haven, CT, 06520, USA. Naila.makhani@yale.edu.; Department of Neurology, Yale University, New Haven, CT, USA. Naila.makhani@yale.edu., Lebrun-Frenay C; CRCSEP Neurologie Pasteur 2, CHU de Nice, Université Cote d'Azur, UMR2CA (URRIS), Nice, France., Siva A; Neuroimmunology Unit, Neurology Department, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey., Shabanova V; Department of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, New Haven, CT, 06520, USA., Wassmer E; Neurology Department, Birmingham Children's Hospital, Aston University, Birmingham, UK., Santoro JD; Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.; Division of Neurology, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, USA., Narula S; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA., Brenton JN; Department of Neurology, University of Virginia, Charlottesville, USA., Mar S; Department of Neurology, Washington University School of Medicine, St. Louis, USA., Durand-Dubief F; Service de sclérose en plaques, Pathologies de la myéline et Neuro-Inflammation, Hôpital Neurologique, Groupement Hospitalier Est, 59 Bd Pinel, 69677, BRON Cedex, France., Zephir H; Inserm UMR-S 1172 LilNcog, Lille University Hospital FHU Precise, Lille University, Lille, France., Mathey G; Department of Neurology, Nancy University Hospital, 54035, Nancy, France., Rojas JI; Hospital Universitario de CEMIC, Buenos Aires, Argentina., de Seze J; Department of Neurology, Hospital Hautepierre, CHU de Strasbourg and Clinical Investigation Center (CIC) INSERM 1434, Strasbourg, France., Tenembaum S; Department of Neurology, National Pediatric Hospital Dr. Juan P Garrahan, Buenos Aires, Argentina., Stone RT; Department of Neurology, University of Rochester Medical Center, Rochester, USA., Casez O; Neurology MS Clinic Grenoble, Grenoble Alpes University Hospital, Grenoble, France.; T-RAIG, TIMC-IMAG, Grenoble Alpes University, Grenoble, France., Carra-Dallière C; Neurology MS Clinic, Montpellier University Hospital, 34295, Montpellier, France.; University of Montpellier (MUSE), 34295, Montpellier, France., Neuteboom RF; Department of Neurology, Erasmus MC Rotterdam, Sophia's Children's Hospital, Rotterdam, The Netherlands., Ahsan N; Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.; Division of Neurology, Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, USA., Arroyo HA; Department of Neurology, Hospital de Pediatría SAMIC. Prof. Dr. J.P. Garrahan, Buenos Aires, Argentina., Cabre P; Centre Hospitalo Universitaire, Fort-de-France, Martinique., Gombolay G; Division of Neurology, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, USA., Inglese M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Department of Neuroscience (DINOGMI), University of Genova, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Louapre C; Assistance Publique Hôpitaux de Paris, Inserm, CNRS, Hôpital de la Pitié Salpêtrière, CIC Neurosciences, Sorbonne Université, Paris Brain Institute - ICM, Paris, France., Margoni M; Department of Neurosciences, Multiple Sclerosis Center of the Veneto Region, University Hospital-School of Medicine, Padua, Italy., Palavra F; Center for Child Development - Neuropaediatrics Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal., Pohl D; Division of Neurology, Children's Hospital of Eastern Ontario, Ottawa, Canada., Reich DS; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA., Ruet A; Department of Neurology, CHU Bordeaux, Bordeaux, France.; INSERM, Neurocentre Magendie, University of Bordeaux, U1215, Bordeaux, France., Thouvenot E; Department of Neurology, Nîmes University Hospital, Nîmes, France.; IGF, University of Montpellier, CNRS, INSERM, Montpellier, France., Timby N; Department of Clinical Sciences/Pediatrics, Umeå University, Umeå, Sweden., Tintore M; Neurology Department, MS Center of Catalunya Cemcat, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona (UAB), UVIC-Universitat Central de Catalunya, Barcelona, Spain., Uygunoglu U; Neuroimmunology Unit, Neurology Department, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey., Vargas W; Department of Neurology, Columbia University Medical Center, New York, USA., Venkateswaran S; Division of Neurology, Children's Hospital of Eastern Ontario, Ottawa, Canada., Verhelst H; Division of Pediatric Neurology, Department of Pediatrics, University Hospital Ghent, Ghent, Belgium., Wickstrom R; Neuropaediatric Unit, Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Azevedo CJ; Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA., Kantarci O; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Shapiro ED; Department of Pediatrics, Yale University, LMP 3088, 333 Cedar Street, New Haven, CT, 06520, USA., Okuda DT; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, USA., Pelletier D; Department of Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2024 Jul; Vol. 271 (7), pp. 4019-4027. Date of Electronic Publication: 2024 Apr 02.
DOI: 10.1007/s00415-024-12289-1
Abstrakt: Background: Cerebrospinal fluid (CSF) and spinal MRIs are often obtained in children with the radiologically isolated syndrome (RIS) for diagnosis and prognosis. Factors affecting the frequency and timing of these tests are unknown.
Objective: To determine whether age or sex were associated with (1) having CSF or spinal MRI obtained or (2) the timing of these tests.
Methods: We analyzed children (≤ 18 y) with RIS enrolled in an international longitudinal study. Index scans met 2010/2017 multiple sclerosis (MS) MRI criteria for dissemination in space (DIS). We used Fisher's exact test and multivariable logistic regression (covariates = age, sex, MRI date, MRI indication, 2005 MRI DIS criteria met, and race).
Results: We included 103 children with RIS (67% girls, median age = 14.9 y). Children ≥ 12 y were more likely than children < 12 y to have CSF obtained (58% vs. 21%, adjusted odds ratio [AOR] = 4.9, p = 0.03). Pre-2017, girls were more likely than boys to have CSF obtained (n = 70, 79% vs. 52%, AOR = 4.6, p = 0.01), but not more recently (n = 30, 75% vs. 80%, AOR = 0.2, p = 0.1; p = 0.004 for interaction). Spinal MRIs were obtained sooner in children ≥ 12 y (median 11d vs. 159d, p = 0.03).
Conclusions: Younger children with RIS may be at continued risk for misdiagnosis and misclassification of MS risk. Consensus guidelines are needed.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
Externí odkaz: