Afadin-nectin forces its way to the front.
| Autor: | Sebbagh M; Aix-Marseille University, Inserm, DyNaMo, Turing Centre of Living Systems, Marseille, France., Schwartz MA; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine and Departments of Cell Biology and Biomedical Engineering, Yale University, New Haven, CT, USA. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of cell biology [J Cell Biol] 2024 May 06; Vol. 223 (5). Date of Electronic Publication: 2024 Apr 02. |
| DOI: | 10.1083/jcb.202403177 |
| Abstrakt: | Force transmission at cell-cell junctions critically regulates embryogenesis, tissue homeostasis, and diseases including cancer. The cadherin-catenin linkage has been considered the keystone of junctional force transmission, but new findings challenge this paradigm, arguing instead that the nectin-afadin linkage plays the more important role in mature junctions in the intestinal epithelium. (© 2024 Sebbagh and Schwartz.) |
| Databáze: | MEDLINE |
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