Language Abnormalities in Alzheimer's Disease Arise from Reduced Informativeness: A Cross-Linguistic Study in English and Persian.
| Autor: | Bayat S, Santai M, Panahi MM, Khodadadi A, Ghassimi M, Rezaei S, Besharat S, Mahboubi Z, Almasi M, Sanei Taheri M, Dickerson BC, Rezaii N |
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| Jazyk: | angličtina |
| Zdroj: | MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 22. Date of Electronic Publication: 2024 Mar 22. |
| DOI: | 10.1101/2024.03.19.24304407 |
| Abstrakt: | Introduction: This research investigates the psycholinguistic origins of language impairments in Alzheimer's Disease (AD), questioning if these impairments result from language-specific structural disruptions or from a universal deficit in generating meaningful content. Methods: Cross-linguistic analysis was conducted on language samples from 184 English and 52 Persian speakers, comprising both AD patients and healthy controls, to extract various language features. Furthermore, we introduced a machine learning-based metric, Language Informativeness Index (LII), to quantify informativeness. Results: Indicators of AD in English were found to be highly predictive of AD in Persian, with a 92.3% classification accuracy. Additionally, we found robust correlations between the typical linguistic abnormalities of AD and language emptiness (low LII) across both languages. Discussion: Findings suggest AD linguistics impairments are attributed to a core universal difficulty in generating informative messages. Our approach underscores the importance of incorporating biocultural diversity into research, fostering the development of inclusive diagnostic tools. Competing Interests: CONFLICTS OF INTEREST STATEMENT The authors declare no conflicts of interest. Author disclosures are available in the supporting information. |
| Databáze: | MEDLINE |
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