Weak coupling of neurons enables very high-frequency and ultra-fast oscillations through the interplay of synchronized phase shifts.

Autor:	Přibylová L; Department of Mathematics and Statistics, Faculty of Science, Masaryk University, Brno, Czech Republic., Ševčík J; Department of Mathematics and Statistics, Faculty of Science, Masaryk University, Brno, Czech Republic., Eclerová V; Department of Mathematics and Statistics, Faculty of Science, Masaryk University, Brno, Czech Republic., Klimeš P; Institute of Scientific Instruments, The Czech Academy of Sciences, Brno, Czech Republic., Brázdil M; Brno Epilepsy Center, Dept. of Neurology, St. Anne's Univ. Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic, member of the ERN EpiCARE.; Behavioral and Social Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Meijer HGE; Department of Applied Mathematics, Techmed Centre, University of Twente, Enschede, The Netherlands.
Jazyk:	angličtina
Zdroj:	Network neuroscience (Cambridge, Mass.) [Netw Neurosci] 2024 Apr 01; Vol. 8 (1), pp. 293-318. Date of Electronic Publication: 2024 Apr 01 (Print Publication: 2024).
DOI:	10.1162/netn_a_00351
Abstrakt:	Recently, in the past decade, high-frequency oscillations (HFOs), very high-frequency oscillations (VHFOs), and ultra-fast oscillations (UFOs) were reported in epileptic patients with drug-resistant epilepsy. However, to this day, the physiological origin of these events has yet to be understood. Our study establishes a mathematical framework based on bifurcation theory for investigating the occurrence of VHFOs and UFOs in depth EEG signals of patients with focal epilepsy, focusing on the potential role of reduced connection strength between neurons in an epileptic focus. We demonstrate that synchronization of a weakly coupled network can generate very and ultra high-frequency signals detectable by nearby microelectrodes. In particular, we show that a bistability region enables the persistence of phase-shift synchronized clusters of neurons. This phenomenon is observed for different hippocampal neuron models, including Morris-Lecar, Destexhe-Paré, and an interneuron model. The mechanism seems to be robust for small coupling, and it also persists with random noise affecting the external current. Our findings suggest that weakened neuronal connections could contribute to the production of oscillations with frequencies above 1000 Hz, which could advance our understanding of epilepsy pathology and potentially improve treatment strategies. However, further exploration of various coupling types and complex network models is needed. Competing Interests: Competing Interests: The authors have declared that no competing interests exist. (© 2024 Massachusetts Institute of Technology.)
Databáze:	MEDLINE
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