7T MRI detects widespread brain iron deposition in neuroferritinopathy.

Autor: Murley AG; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Rua C; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.; Invicro, London, UK., Biggs H; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Rodgers CT; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK., Matys T; Department of Radiology, University of Cambridge, Cambridge, UK., van den Ameele J; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Horvath R; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Chinnery PF; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2024 May; Vol. 11 (5), pp. 1359-1364. Date of Electronic Publication: 2024 Apr 01.
DOI: 10.1002/acn3.52053
Abstrakt: Neuroferritinopathy is a disorder of neurodegeneration with brain iron accumulation that has no proven disease-modifying treatments. Clinical trials require biomarkers of iron deposition. We examined brain iron accumulation in one presymptomatic FTL mutation carrier, two individuals with neuroferritinopathy and one healthy control using ultra-high-field 7T MRI. There was increased magnetic susceptibility, suggestive of iron deposition, in superficial and deep gray matter in both presymptomatic and symptomatic neuroferritinopathy. Cavitation of the putamen and globus pallidus increased with disease stage and at follow up. The widespread brain iron deposition in presymptomatic and early disease provides an opportunity for monitoring disease-modifying intervention.
(© 2024 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze: MEDLINE
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