Near-infrared fluorescence-assisted superficial inguinal lymph-node excision for low-risk penile cancer.

Autor: Yan X; First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001, People's Republic of China.; Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, People's Republic of China., Liu C; Academy of Medical Sciences, Shanxi Medical University, Taiyuan, 030001, People's Republic of China., Cui L; Academy of Medical Sciences, Shanxi Medical University, Taiyuan, 030001, People's Republic of China., Yan P; First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001, People's Republic of China., Fu X; First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001, People's Republic of China., Chen W; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, People's Republic of China. chenweiyi@tyut.edu.cn., Yang X; First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001, People's Republic of China. yxfylq@163.com.; Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, People's Republic of China. yxfylq@163.com.
Jazyk: angličtina
Zdroj: World journal of urology [World J Urol] 2024 Apr 01; Vol. 42 (1), pp. 206. Date of Electronic Publication: 2024 Apr 01.
DOI: 10.1007/s00345-024-04877-7
Abstrakt: Objective: Identification of superficial inguinal lymph nodes during low-risk penile cancer surgery using near-infrared (NIR) fluorescence to improve the accuracy of lymph-node dissection and reduce the incidence of missed micrometastases and complications.
Methods: Thirty-two cases were selected, which were under the criteria of < T1, and no lymph-node metastasis was found with magnetic resonance imaging (MRI) detection. Two groups were randomly divided based on the fluorescence technique, the indocyanine green (ICG) group and the non-ICG group. In the ICG group, the ICG preparation was subcutaneously injected into the edge of the penile tumor 10 min before surgery, and the near-infrared fluorescence imager was used for observation. After the lymph nodes were visualized, the superficial inguinal lymph nodes were removed first, and then, the penis surgery was performed. The non-ICG group underwent superficial inguinal lymph-node dissection and penile surgery.
Results: Among the 16 patients in the ICG group, we obtained 11 lymph-node specimens using grayscale values of images (4.13 ± 0.72 vs. 3.00 ± 0.82 P = 0.003) along with shorter postoperative healing time (7.31 ± 1.08 vs. 8.88 ± 2.43 P = 0.025), and less lymphatic leakage (0 vs. 5 P = 0.04) than the 16 patients in the non-ICG group. Out of 11, 3 lymph nodes that are excised were further grouped into fluorescent and non-fluorescent regions (G1/G2) and found to be metastasized.
Conclusion: Near-infrared fluorescence-assisted superficial inguinal lymph-node dissection in penile carcinoma is accurate and effective, and could reduce surgical complications.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: