Longitudinal tracking of intrabreath respiratory impedance in preschool children.

Autor: Wong MD; Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia., Blake TL; Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia., Zahir SF; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Suresh S; Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Hantos Z; Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.; Department of Anesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary., Grimwood K; School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia.; Departments of Infectious Disease and Paediatrics, Gold Coast Health, Southport, Queensland, Australia., Lambert SB; The University of Queensland Centre for Clinical Research, Herston, Queensland, Australia.; National Centre for Immunisation Research and Surveillance, Westmead, New South Wales, Australia., Ware RS; School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia., Sly PD; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Jazyk: angličtina
Zdroj: Pediatric pulmonology [Pediatr Pulmonol] 2024 Jul; Vol. 59 (7), pp. 1885-1893. Date of Electronic Publication: 2024 Apr 01.
DOI: 10.1002/ppul.26994
Abstrakt: Background: Longitudinal measurements of intrabreath respiratory impedance (Zrs) in preschool-aged children may be able to distinguish abnormal lung function trajectories in children with a history of wheezing compared to healthy ones.
Methods: Children from a prospective, longitudinal community-based cohort performed annual intrabreath oscillometry (IB-OSC) measurements from age 3- to 7-years. IB-OSC was performed using a single 10 Hz sinusoid while clinically asymptomatic. Linear mixed-effects models were developed to explore the effects of wheezing phenotypes, growth, and sex on seven IB-OSC outcome variables over time: resistance at end-expiration (ReE), resistance at end-inspiration (ReI), the tidal change in resistance (∆R=ReE-ReI), reactance at end-expiration (XeE), reactance at end-inspiration (XeI), the tidal change in reactance (∆X=XeE-XeI), and ∆X normalized by tidal volume (∆X/V T ).
Results: Eighty-five children produced 374 acceptable IB-OSC measurements. Subjects were classified into one of three wheeze groups: never (n = 36), transient (n = 34), or persistent (n = 15). After adjusting for height, children with persistent wheezing, compared to those who never wheezed, had +0.814 hPa s L -1 ReE (95% confidence interval [CI] +0.178 to +1.451, p = 0.015), -0.792 hPa s L -1 XeE (95% CI -1.203 to -0.381, p = 0.003), -0.538 hPa s L -1 ∆X (95% CI -0.834 to -0.242, p = 0.007) and -1.672 hPa s L -2 ∆X/V T (95% CI -2.567 to -0.777, p < 0.001). Increasing height had a significant effect on all IB-OSC resistance and reactance variables when adjusted for the effect of preschool wheezing.
Conclusions: IB-OSC is feasible for tracking lung function growth in preschool-aged children and may allow abnormal lung function to be identified early in asymptomatic preschoolers with a history of persistent wheezing.
(© 2024 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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