Lupus nephritis presenting with massive ascites and pleural effusion (pseudo-pseudo Meigs' syndrome).

Autor:	Deniz R; Department of Rheumatology, Başakşehir Çam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey., Hacımurtazaoğlu-Demir G; Department of Internal Medicine, University of Health Sciences Bağcılar Education and Research Hospital, Istanbul, Turkey., Karaalioğlu B; Department of Rheumatology, Başakşehir Çam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey., Özgür DS; Department of Rheumatology, Başakşehir Çam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey., Akkuzu G; Department of Rheumatology, Başakşehir Çam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey., Yıldırım F; Department of Rheumatology, Başakşehir Çam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey., Bes C; Department of Rheumatology, Başakşehir Çam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Journal of rheumatic diseases [J Rheum Dis] 2024 Apr 01; Vol. 31 (2), pp. 116-119. Date of Electronic Publication: 2024 Jan 17.
DOI:	10.4078/jrd.2023.0052
Abstrakt:	The triad of ascites, pleural effusion, and elevated cancer antigen-125 (CA-125) levels in the absence of ovarian malignancy in systemic lupus erythematosus patients is specifically named pseudo-pseudo Meigs' syndrome (PPMS) or Tjalma syndrome. In this case we reported a 33 years female patient with pleural effusion lasting for 3 years and new onset progressive massive ascites and increased level of CA-125. After she was evaluated for an underlying benign and malign ovarian tumor or any other malignancies, serologic tests were requested with respect to progressive renal dysfunction, proteinuria, lymphopenia, anemia, and effusion. She was diagnosed with systemic lupus erythamatosus (SLE) and renal biopsy showed class-V lupus nephritis. Immunosuppressive treatment led to improvement in both SLE activity and components of PPMS, including massive ascites and pleural effusion and without the need of diuretics. Co-existence of unexplained CA-125 increase, pleural effusion, and ascites might be related to PPMS and detailed examination to exclude malignancy and early and effective treatment of SLE are the mainstay of management. Competing Interests: CONFLICT OF INTEREST No potential conflict of interest relevant to this article was reported. (Copyright © 2024 by The Korean College of Rheumatology. All rights reserved.)
Databáze:	MEDLINE
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