Intractable Nocardial mycetoma with possible colonisation by Candida species.

Autor: Sumioki A; Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan., Saito K; Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan., Nishida H; Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Oita, Japan., Nishizono A; Department of Microbiology, Faculty of Medicine, Oita University, Oita, Japan.; Oita University Research Center for Global and Local Infectious Diseases, Oita, Japan., Miyamoto Y; Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan., Ishii N; Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan., Hiruma M; Ochanomizu Institute for Medical Mycology and Allergology, Tokyo, Japan., Shibuya K; Department of Pathophysiology and Infection Control of Fungal Infection, Toho University School of Medicine, Tokyo, Japan., Yaguchi T; Medical Mycology Research Center, Chiba University, Chiba, Japan., Hatano Y; Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan.
Jazyk: angličtina
Zdroj: The Journal of dermatology [J Dermatol] 2024 Oct; Vol. 51 (10), pp. 1364-1367. Date of Electronic Publication: 2024 Apr 01.
DOI: 10.1111/1346-8138.17206
Abstrakt: A Japanese male in his 30s with no underlying medical condition presented with painless nodules after being bitten by a dog during a stay in Bali, Indonesia, 7 years earlier. He was referred to our department with multiple ulcers, nodules, and masses on the right leg. The final diagnosis was mycetoma caused by Nocardia vulneris, which may have been exacerbated by colonization of Candida parapsilosis and C. tropicalis as these yeasts were isolated by culture from the tissue. Treatment with minocycline hydrochloride and sulfamethoxazole trimethoprim showed partial efficacy, but the addition of posaconazole achieved significant efficacy. This suggests that the surmised coexistence of pathogenic yeasts of lower virulency may have made mycetoma in this case intractable.
(© 2024 Japanese Dermatological Association.)
Databáze: MEDLINE
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