Sleep disturbances, altered brain microstructure and chronic headache in youth.

Autor: Vandergaag ID; Biomedical Engineering, Calgary, AB, Canada.; McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada., Nania C; School and Applied Child Psychology, c Psychology, d Radiology, e Anesthesiology, Perioperative & Pain Medicine, University of Calgary, Calgary, AB, Canada., Timmers I; Medical and Clinical Psychology, Tilburg University, Tilburg, Netherlands., Simons L; Biomedical Engineering, Calgary, AB, Canada., Lebel C; Child Brain & Mental Health Program, i Owerko Centre, Alberta Children's Hospital Research Institute, Calgary, AB, Canada.; Hotchkiss Brain Institute, Mathison Centre for Mental Health Research & Education, Calgary, AB, Canada., Rasic N; Child Brain & Mental Health Program, i Owerko Centre, Alberta Children's Hospital Research Institute, Calgary, AB, Canada., Walker A; Biomedical Engineering, Calgary, AB, Canada., Noel M; Child Brain & Mental Health Program, i Owerko Centre, Alberta Children's Hospital Research Institute, Calgary, AB, Canada.; Hotchkiss Brain Institute, Mathison Centre for Mental Health Research & Education, Calgary, AB, Canada., Miller JV; Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA. jillian.miller1@ucalgary.ca.; Child Brain & Mental Health Program, i Owerko Centre, Alberta Children's Hospital Research Institute, Calgary, AB, Canada. jillian.miller1@ucalgary.ca.; Hotchkiss Brain Institute, Mathison Centre for Mental Health Research & Education, Calgary, AB, Canada. jillian.miller1@ucalgary.ca.; Department of Anesthesiology, Perioperative and Pain Medicine, 28 Oki Dr NW, Calgary, AB, T3B 6A8, Canada. jillian.miller1@ucalgary.ca.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 Aug; Vol. 18 (4), pp. 875-883. Date of Electronic Publication: 2024 Apr 01.
DOI: 10.1007/s11682-024-00876-9
Abstrakt: Chronic headache (persistent or recurrent headache for 3-months or longer) is highly prevalent among youth. While sleep disturbances have been associated with headache, their inter-relationship with brain connectivity remains unknown. This observational study examined whether self-report and actigraphy measures of sleep were associated with alterations to white matter tracts (i.e., uncinate fasciculus and cingulum) in youth with chronic headache versus healthy controls. Thirty youth aged 10-18 years with chronic headache and thirty controls underwent an MRI. Diffusion tensor images were obtained and mean fractional anisotropy values of the cingulum and uncinate were extracted. One-week prior to their MRI, youth wore an actigraph to obtain sleep duration, wake after sleep onset and sleep efficiency measures. Moreover, they completed questionnaires regarding their sleep quality and pain symptomatology. Linear regression was applied to examine the relationships between sleep (self-report and actigraphy), fractional anisotropy, and number of headache days per month. Self-report and actigraphy measures of sleep did not differ between patients and controls. However, poorer self-reported sleep quality was associated with lower fractional anisotropy values in the left uncinate (P = 0.05). Lower left uncinate fractional anisotropy was related to increased headache frequency (P = 0.002) in youth with chronic headache. Therefore, alterations to connectivity may be associated with the relationship between altered perceptions of sleep and headache chronicity.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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