Living in Syn: T Cell Antigen Identification Based on Synapse Sequencing.
| Autor: | Makani VKK; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Joglekar AV; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer immunology research [Cancer Immunol Res] 2024 May 02; Vol. 12 (5), pp. 515. |
| DOI: | 10.1158/2326-6066.CIR-24-0239 |
| Abstrakt: | The pivotal role of T cell responses has been well studied in both protective and destructive scenarios. T cells recognize peptide epitopes presented on Human Leukocyte Antigens (HLA) through their surface T cell receptors (TCR). Advances in single-cell RNA sequencing have identified millions of TCRs, but only a minuscule fraction of them have known epitopes. Recently, cell-based T cell antigen discovery platforms have emerged onto the landscape. Here, Jin and colleagues, report a novel antigen discovery platform called Tsyn-seq that relies on sequencing TCR-peptide-HLA-induced synapses for genome-wide epitope screening. See related article by Jin et al., p. 530 (3). (©2024 American Association for Cancer Research.) |
| Databáze: | MEDLINE |
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