Lifestyle-related factors in late midlife as predictors of frailty from late midlife into old age: a longitudinal birth cohort study.

Autor:	Haapanen MJ; Public Health Research Program, Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mikkola TM; Public Health Research Program, Folkhälsan Research Center, Helsinki, Finland.; Public Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.; Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Jylhävä J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Faculty of Social Sciences (Health Sciences) and Gerontology Research Center, Tampere University, Tampere, Finland., Wasenius NS; Public Health Research Program, Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland., Kajantie E; Public Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.; Clinical Medicine Research Unit, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Children's Hospital, Helsinki University Hospital, Helsinki, Finland., Eriksson JG; Public Health Research Program, Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Yong Loo Lin School of Medicine, Department of Obstetrics and Gynecology and Human Potential Translational Research Programme, National University Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Brenner Centre for Molecular Medicine, Singapore., von Bonsdorff MB; Public Health Research Program, Folkhälsan Research Center, Helsinki, Finland.; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Jazyk:	angličtina
Zdroj:	Age and ageing [Age Ageing] 2024 Apr 01; Vol. 53 (4).
DOI:	10.1093/ageing/afae066
Abstrakt:	Background: Few studies have examined longitudinal changes in lifestyle-related factors and frailty. Methods: We examined the association between individual lifestyle factors (exercise, diet, sleep, alcohol, smoking and body composition), their sum at baseline, their change over the 17-year follow-up and the rate of change in frailty index values using linear mixed models in a cohort of 2,000 participants aged 57-69 years at baseline. Results: A higher number of healthy lifestyle-related factors at baseline was associated with lower levels of frailty but not with its rate of change from late midlife into old age. Participants who stopped exercising regularly (adjusted β × Time = 0.19, 95%CI = 0.10, 0.27) and who began experiencing sleeping difficulties (adjusted β × Time = 0.20, 95%CI = 0.10, 0.31) experienced more rapid increases in frailty from late midlife into old age. Conversely, those whose sleep improved (adjusted β × Time = -0.10, 95%CI = -0.23, -0.01) showed a slower increase in frailty from late midlife onwards. Participants letting go of lifestyle-related factors (decline by 3+ factors vs. no change) became more frail faster from late midlife into old age (adjusted β × Time = 0.16, 95% CI = 0.01, 0.30). Conclusions: Lifestyle-related differences in frailty were already evident in late midlife and persisted into old age. Adopting one new healthy lifestyle-related factor had a small impact on a slightly less steeply increasing level of frailty. Maintaining regular exercise and sleeping habits may help prevent more rapid increases in frailty. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Geriatrics Society.)
Databáze:	MEDLINE
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