Cistus incanus : a natural source of antimicrobial metabolites.

Autor: De Filippis A; Department of Experimental Medicine, section of Microbiology and Clinical Microbiology, University of Campania 'L. Vanvitelli', Naples, Italy., D'Amelia V; Institute of Bioscience and BioResources, National Research Council, Portici, Italy.; Immunoveg s.r.l. c/o, Portici, Italy., Folliero V; Department of Experimental Medicine, section of Microbiology and Clinical Microbiology, University of Campania 'L. Vanvitelli', Naples, Italy., Zannella C; Department of Experimental Medicine, section of Microbiology and Clinical Microbiology, University of Campania 'L. Vanvitelli', Naples, Italy., Franci G; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy., Galdiero M; Department of Experimental Medicine, section of Microbiology and Clinical Microbiology, University of Campania 'L. Vanvitelli', Naples, Italy., Di Loria A; Immunoveg s.r.l. c/o, Portici, Italy.; Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy., Laezza C; Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy., Monti SM; Immunoveg s.r.l. c/o, Portici, Italy.; Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy., Piccinelli AL; Department of Pharmacy, University of Salerno, Fisciano, Italy.; National Biodiversity Future Center, NBFC, Palermo, Italy., Celano R; Department of Pharmacy, University of Salerno, Fisciano, Italy.; National Biodiversity Future Center, NBFC, Palermo, Italy., Rigano MM; Immunoveg s.r.l. c/o, Portici, Italy.; Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 Apr 01, pp. 1-14. Date of Electronic Publication: 2024 Apr 01.
DOI: 10.1080/14786419.2024.2335353
Abstrakt: The discovery of natural molecules with antimicrobial properties has become an urgent need for the global treatment of bacterium and virus infections. Cistus incanus , a Mediterranean shrub species, represents a valuable source of phytochemicals with an interesting wide-spectrum antimicrobial potential. In this study, we analysed the spectrum of molecules composing a commercial hydroalcoholic extract of C. incanus finding ellagitannins as the most abundant. The effect of the extract and its main constituents (gallic acid, ellagic acid and punicalin) was assessed as co-treatment during viral (HSV-1, HCoV-229E, SARS-CoV-2) and bacterial infection ( Staphylococcus aureus and Escherichia coli ) of cells and as pre-treatment before virus infections. The results indicated a remarkable antiviral activity of punicalin against SARS-CoV-2 by pre-treating both the viral and the host cells, and a major sensitivity of S. aureus to the C. incanus extract compared to E. coli . The present study highlights broad antimicrobial potential of C. incanus extract.
Databáze: MEDLINE