Nonwoven fiber meshes for oxygen sensing.

Autor: Salaris N; Nanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London, WC1E 7JE, United Kingdom; Wellcome/EPSRC Centre for Interventional and Surgical Sciences-WEISS, University College London, London, W1W 7TS, United Kingdom., Chen W; Nanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London, WC1E 7JE, United Kingdom; Wellcome/EPSRC Centre for Interventional and Surgical Sciences-WEISS, University College London, London, W1W 7TS, United Kingdom., Haigh P; School of Engineering, Newcastle University, Newcastle, NE1 7RU, United Kingdom., Caciolli L; Wellcome/EPSRC Centre for Interventional and Surgical Sciences-WEISS, University College London, London, W1W 7TS, United Kingdom; NIHR Biomedical Research Centre, Stem Cells and Regenerative Medicine, Developmental Biology and Cancer Programme, UCL GOS ICH Zayed Centre for Research Into Rare Disease in Children, 20 Guilford Street, London, WC1N 1DZ, United Kingdom., Giobbe GG; NIHR Biomedical Research Centre, Stem Cells and Regenerative Medicine, Developmental Biology and Cancer Programme, UCL GOS ICH Zayed Centre for Research Into Rare Disease in Children, 20 Guilford Street, London, WC1N 1DZ, United Kingdom., De Coppi P; NIHR Biomedical Research Centre, Stem Cells and Regenerative Medicine, Developmental Biology and Cancer Programme, UCL GOS ICH Zayed Centre for Research Into Rare Disease in Children, 20 Guilford Street, London, WC1N 1DZ, United Kingdom; Dept. of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK., Papakonstantinou I; Photonic Innovations Lab, Department of Electronic and Electrical Engineering, University College London, London, WC1E 7JE, United Kingdom., Tiwari MK; Nanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London, WC1E 7JE, United Kingdom; Wellcome/EPSRC Centre for Interventional and Surgical Sciences-WEISS, University College London, London, W1W 7TS, United Kingdom. Electronic address: m.tiwari@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Biosensors & bioelectronics [Biosens Bioelectron] 2024 Jul 01; Vol. 255, pp. 116198. Date of Electronic Publication: 2024 Mar 27.
DOI: 10.1016/j.bios.2024.116198
Abstrakt: Accurate oxygen sensing and cost-effective fabrication are crucial for the adoption of wearable devices inside and outside the clinical setting. Here we introduce a simple strategy to create nonwoven polymeric fibrous mats for a notable contribution towards addressing this need. Although morphological manipulation of polymers for cell culture proliferation is commonplace, especially in the field of regenerative medicine, non-woven structures have not been used for oxygen sensing. We used an airbrush spraying, i.e. solution blowing, to obtain nonwoven fiber meshes embedded with a phosphorescent dye. The fibers serve as a polymer host for the phosphorescent dye and are shown to be non-cytotoxic. Different composite fibrous meshes were prepared and favorable mechanical and oxygen-sensing properties were demonstrated. A Young's modulus of 9.8 MPa was achieved and the maximum oxygen sensitivity improved by a factor of ∼2.9 compared to simple drop cast film. The fibers were also coated with silicone rubbers to produce mechanically robust sensing films. This reduced the sensing performance but improved flexibility and mechanical properties. Lastly, we are able to capture oxygen concentration maps via colorimetry using a smartphone camera, which should offer unique advantages in wider usage. Overall, the introduced composite fiber meshes show a potential to significantly improve cell cultures and healthcare monitoring via absolute oxygen sensing.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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